Targeted therapies for microvascular disease

Bland, A., Chuah, E., Meere, W. and Ford, T. J. (2024) Targeted therapies for microvascular disease. Cardiology Clinics, 42(1), pp. 137-145. (doi: 10.1016/j.ccl.2023.07.002) (PMID:37949535)

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Abstract

Coronary microvascular dysfunction (CMD) is a common cause of ischemia but no obstructive coronary artery disease that results in an inability of the coronary microvasculature to meet myocardial oxygen demand. CMD is challenging to diagnose and manage due to a lack of mechanistic research and targeted therapy. Recent evidence suggests we can improved patient outcomes by stratifying antianginal therapies according to the diagnosis revealed by invasive assessment of the coronary microcirculation. This review article appraises the evidence for management of CMD, which includes treatment of cardiovascular risk, antianginal therapy and therapy for atherosclerosis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ford, Thomas
Authors: Bland, A., Chuah, E., Meere, W., and Ford, T. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Cardiology Clinics
Publisher:Elsevier
ISSN:0733-8651
ISSN (Online):1558-2264
Published Online:08 November 2023

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