New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line

Draoui, Y., Radi, S., Bahjou, Y., Idir, A., El Mahdaoui, A., Zyad, A., Miras, H. N. , Ferbinteanu, M., Rotaru, A. and Garcia, Y. (2023) New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line. RSC Advances, 13(51), pp. 36158-36167. (doi: 10.1039/d3ra07714d) (PMID:38090097) (PMCID:PMC10714199)

Abstract

The present work describes the synthesis of a new triazole based ligand 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1-methyl-1H-1,2,4-triazole (LM) and demonstration of its coordination diversity giving rise to a family of seven new coordination complexes, namely: [Ni(LM)3](ClO4)2·C2H6OS (5), [Co2(LM)6](ClO4)4·(C2H5)O (6), [Cd(LM)2Cl2] (7), [Cu(LM)2NO3]NO3 (8), [Fe(LM)3](BF4)2 (9), [Zn(LM)3](BF4)2 (10) and [Zn(LM)2NO3]NO3 (11), whose crystal structure was determined by single-crystal X-ray diffraction. Cytotoxic activity was evaluated against the MDA-MB-468 cancer cell line, which serves as a model for triple-negative breast cancer, and compared to the precursor molecule (L), as well as their coordination complexes (H3O){[NiL3](ClO4)3} (1), [CoL3](ClO4)2·2H2O (2), [CdL2Cl2] (3) and [CuL3](NO3)2 (4), for which the crystal structure was earlier determined. Notably, cadmium complexes 3 and 7 exhibit remarkable cytotoxicity and demonstrated a high selectivity index towards cancer cells when compared to peripheral blood mononuclear cells. Such activity highlights their potential function as anticancer agents.

• Item Type: Articles
• Additional Information: This research was supported by the PPR2-MESRSFC-CNRST-P10 project (Morocco), the COST action CA21149, the Fonds De La Recherche Scientifique—FNRS (CDR J.0064.23, PDR T.0095.21), ARES for a PhD grant to YB, and UEFISCDI (HighSensSpin, TE 77/2022 (PN-III-P1-1.1-TE-2021-1654)).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Moiras, Professor Haralampos
• Authors: Draoui, Y., Radi, S., Bahjou, Y., Idir, A., El Mahdaoui, A., Zyad, A., Miras, H. N., Ferbinteanu, M., Rotaru, A., and Garcia, Y.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: RSC Advances
• Publisher: Royal Society of Chemistry
• ISSN: 2046-2069
• ISSN (Online): 2046-2069
• Published Online: 11 December 2023
• Copyright Holders: Copyright © 2023 The Author(s)
• First Published: First published in RSC Advances 13(51):36158-36167
• Publisher Policy: Reproduced under a Creative Commons license