Lam, C. S.P., Docherty, K. F. , Ho, J. E., McMurray, J. J.V. , Myhre, P. L. and Omland, T. (2023) Recent successes in heart failure treatment. Nature Medicine, 29(10), pp. 2424-2437. (doi: 10.1038/s41591-023-02567-2) (PMID:37814060)
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Abstract
Remarkable recent advances have revolutionized the field of heart failure. Survival has improved among individuals with heart failure and a reduced ejection fraction and for the first time, new therapies have been shown to improve outcomes across the entire ejection fraction spectrum of heart failure. Great strides have been taken in the treatment of specific cardiomyopathies such as cardiac amyloidosis and hypertrophic cardiomyopathy, whereby conditions once considered incurable can now be effectively managed with novel genetic and molecular approaches. Yet there remain substantial residual unmet needs in heart failure. The translation of successful clinical trials to improved patient outcomes is limited by large gaps in implementation of care, widespread lack of disease awareness and poor understanding of the socioeconomic determinants of outcomes and how to address disparities. Ongoing clinical trials, advances in phenotype segmentation for precision medicine and the rise in technology solutions all offer hope for the future.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Docherty, Dr Kieran and McMurray, Professor John |
| Authors: | Lam, C. S.P., Docherty, K. F., Ho, J. E., McMurray, J. J.V., Myhre, P. L., and Omland, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Nature Medicine |
| Publisher: | Nature Research |
| ISSN: | 1078-8956 |
| ISSN (Online): | 1546-170X |
| Published Online: | 09 October 2023 |
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