Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis

FitzGerald, O. et al. (2023) Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis. Therapeutic Advances in Musculoskeletal Disease, 15, pp. 1-14. (doi: 10.1177/1759720x231192315) (PMID:37694182) (PMCID:PMC10492462)

Abstract

Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many cases, failure to adequately suppress inflammatory disease features. Single-centre studies have certainly contributed to our understanding of disease pathogenesis, but to adequately address the major areas of unmet need, multi-partner, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centres experienced in PsA research, 5 pharmaceutical industry partners, 3 small-/medium-sized industry partners and 2 patient-representative organizations. In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing and treating PsA allowing for better short-term and long-term outcomes.

• Item Type: Articles
• Additional Information: unding The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: HIPPOCRATES has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement no. 101007757. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. AV is funded by a National Institute for Health Research fellowship. The work was supported by the National Institute for Health Research (NIHR) Oxford and Manchester Biomedical Research Centres.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Siebert, Professor Stefan and Goodyear, Professor Carl
• Authors: FitzGerald, O., Behrens, F., Barton, A., Bertheussen, H., Boutouyrie-Dumont, B., Coates, L., Davies, O., de Wit, M., Fagni, F., Goodyear, C. S., Gurke, R., Hahnefeld, L., Huppertz, C., Ioannidis, V., Ibberson, M., Katz, A., Klippstein, M., Koehm, M., Korish, S., Mackay, S., Martin, D. A., O'Sullivan, D., Patel, K., Rueping, S., Schett, G., Scholich, K., Schwenk, J. M., Siebert, S., Simon, D., Vivekanantham, A., and Pennington, S. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Therapeutic Advances in Musculoskeletal Disease
• Publisher: SAGE Publications
• ISSN: 1759-720X
• ISSN (Online): 1759-7218
• Published Online: 08 September 2023
• Copyright Holders: Copyright © The Author(s), 2023
• First Published: First published in Therapeutic Advances in Musculoskeletal Disease 15:1-14
• Publisher Policy: Reproduced under a Creative Commons license