Lala, A. et al. (2024) Standardized definitions for evaluation of acute decompensated heart failure therapies. JACC: Heart Failure, 12(1), pp. 1-15. (doi: 10.1016/j.jchf.2023.09.030) (PMID:38069997)
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Abstract
Acute decompensated heart failure (ADHF) is one of the most common reasons for hospitalizations or urgent care and is associated with poor outcomes. Therapies shown to improve outcomes are limited, however, and innovation in pharmacologic and device-based therapeutics are therefore actively being sought. Standardizing definitions for ADHF and its trajectory is complex, limiting the generalizability and translation of clinical trials to effect clinical care and policy change. The Heart Failure Collaboratory is a multi-stakeholder organization comprising clinical investigators, clinicians, patients, government representatives (including U.S. Food and Drug Administration and National Institutes of Health participants), payors, and industry collaborators. The following expert consensus document is the product of the Heart Failure Collaboratory convening with the Academic Research Consortium, including members from academia, the U.S. Food and Drug Administration, and industry, for the purposes of proposing standardized definitions for ADHF and highlighting important endpoint considerations to inform the design and conduct of clinical trials for drugs and devices in this clinical arena.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McMurray, Professor John |
| Authors: | Lala, A., Hamo, C. E., Bozkurt, B., Fiuzat, M., Blumer, V., Bukhoff, D., Butler, J., Costanzo, M. R., Felker, G. M., Filippatos, G., Konstam, M. A., McMurray, J. J.V., Mentz, R. J., Metra, M., Psotka, M. A., Solomon, S. D., Teerlink, J., Abraham, W. T., and O’Connor, C. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | JACC: Heart Failure |
| Publisher: | Elsevier |
| ISSN: | 2213-1779 |
| ISSN (Online): | 2213-1787 |
| Published Online: | 06 December 2023 |
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