Precision nutrition in pediatric IBD: a position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals

Gerasimidis, K. et al. (2024) Precision nutrition in pediatric IBD: a position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals. Journal of Pediatric Gastroenterology and Nutrition, 78(2), pp. 428-445. (doi: 10.1002/jpn3.12096) (PMID:38374554)

Abstract

Stratified and precision nutrition refers to disease management or prevention of disease onset, based on dietary interventions tailored to a person's characteristics, biology, gut microbiome, and environmental exposures. Such treatment models may lead to more effective management of inflammatory bowel disease (IBD) and reduce risk of disease development. This societal position paper aimed to report advances made in stratified and precision nutritional therapy in IBD. Following a structured literature search, limited to human studies, we identified four relevant themes: (a) nutritional epidemiology for risk prediction of IBD development, (b) food-based dietary interventions in IBD, (c) exclusive enteral nutrition (EEN) for Crohn's disease (CD) management, and (d) pre- and probiotics for IBD management. There is scarce literature upon which we can make recommendations for precision or stratified dietary therapy for IBD, both for risk of disease development and disease management. Certain single-nucleotide polymorphisms related to polyunsaturated fatty acid (PUFA) metabolism may modify the effect dietary PUFA have in increasing the risk of IBD development. Non-colonic CD, mild-to-moderate CD, and high microbiota richness may predict success of EEN and may be used both for prediction of treatment continuation, but also for early cessation in nonresponders. There is currently insufficient evidence to make recommendations for precision or stratified dietary therapy for patients with established IBD. Despite the great interest in stratified and precision nutrition, we currently lack data to support conclusive recommendations. Replication of early findings by independent research groups and within structured clinical interventions is required.

• Item Type: Articles
• Keywords: Exclusive enteral nutrition (EEN), inflammatory bowel disease (IBD), precision nutrition, prediction, stratified nutrition.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gkikas, Dr Konstantinos and Russell, Dr Richard and Gerasimidis, Professor Konstantinos
• Authors: Gerasimidis, K., Russell, R. K., Giachero, F., Gkikas, K., Tel, B., Assa, A., Bronsky, J., de Ridder, L., Hojsak, I., Jenke, A., Norsa, L., Signall-Boneh, R., Sila, S., Wine, E., Zilbauer, M., Strisciuglio, C., and Gasparetto, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Pediatric Gastroenterology and Nutrition
• Publisher: Wiley
• ISSN: 0277-2116
• ISSN (Online): 1536-4801
• Published Online: 27 December 2023
• Copyright Holders: Copyright © 2023 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
• First Published: First published in Journal of Pediatric Gastroenterology and Nutrition 78(2):428-445
• Publisher Policy: Reproduced in accordance with the publisher copyright policy