Zhuo, Y., He, J., Wang, L., Chow, C. B. and Ho, F. K. (2024) Association between birth weight and insulin resistance in US adolescents: a retrospective cohort study exploring the role of concurrent body mass index. Nutrition, Metabolism and Cardiovascular Diseases, 34(4), pp. 1061-1068. (doi: 10.1016/j.numecd.2023.11.016) (PMID:38331646)
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Abstract
Background and aims: This study aimed to investigate the association between birth weight (BW) and abnormal HOMA-IR in US adolescents aged 12–15 years. The role of concurrent body mass index (BMI) in adolescence was also examined. Methods and results: This retrospective cohort study included 3429 participants from NHANES with data in 1999–2020. HOMA-IR ≥2.3 was considered abnormal. Participants were classified as low (LBW; <2.5 kg), normal (NBW; 2.5–4.0 kg), or high (HBW; >4.0 kg) BW. Logistic regression was used to explore the association between BW and HOMA-IR. Mediation analysis was used to examine whether BMI z-score in adolescence mediated the association between BW and HOMA-IR. Compared with those in NBW, the odds ratios (95 % CI) of abnormal HOMA-IR in LBW and HBW groups were 1.26 (0.99–1.60), and 0.62 (0.47–0.83) respectively. The association between BW and abnormal HOMA-IR was consistent in all subgroups with no significant interactions. Mediation analysis showed that BW is associated with lower risk of HOMA-IR directly, but with higher risk indirectly via BMI in adolescence. Conclusion: There was a negative linear relationship between BW and the prevalence of abnormal HOMA-IR in adolescents aged 12–15 independent of concurrent BMI. Children who were born with LBW but had high BMI in adolescence were of particularly higher risk of insulin resistance.
Item Type: | Articles |
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Keywords: | Birth weight, HOMA-IR, BMI, adolescents, NHANES database. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ho, Dr Frederick |
Creator Roles: | |
Authors: | Zhuo, Y., He, J., Wang, L., Chow, C. B., and Ho, F. K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
Journal Name: | Nutrition, Metabolism and Cardiovascular Diseases |
Publisher: | Elsevier |
ISSN: | 0939-4753 |
ISSN (Online): | 1590-3729 |
Published Online: | 29 November 2023 |
Copyright Holders: | Copyright © 2023 The Author(s) |
First Published: | First published in Nutrition, Metabolism and Cardiovascular Diseases 34(4):1061-1068 |
Publisher Policy: | Reproduced under a Creative Commons license |
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