Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion

Lappin, D. F., Thomas, S., Bennett, D., Nile, C. and Riggio, M. P. (2024) Elevated pro-inflammatory cytokines and chemokines in saliva of cats with feline odontoclastic resorptive lesion. Research in Veterinary Science, 166, 105092. (doi: 10.1016/j.rvsc.2023.105092) (PMID:38029490)

Abstract

Feline odontoclastic resorptive lesion (FORL) is an inflammatory oral disease of unknown aetiopathogenesis that affects between 20% to 75% of cats. Twenty immune-associated molecules were measured in saliva of 25 healthy and 40 cats with FORL using a multiplex assay. No statistically significant differences were observed in the levels of these proteins between the healthy group and the diseased group of cats. A two-step cluster analysis of the oral microbiome and salivary cytokine data identified two subgroups of cats with FORL: FORL-1 (subset of cats with a less diverse oral microbiome) and FORL-2 (diseased cats with a microbiome similar to that of healthy animals). The level of some key proinflammatory cytokines (IL-1β, IL-12p40) and chemokines (IL-8, RANTES, KC) were significantly higher in the FORL-1 subgroup than in the FORL-2 subgroup and the healthy group. In addition, TNF-α levels were greater in the FORL-1 subgroup than in the FORL-2 subgroup. These increases in pro-inflammatory cytokines and chemokines indicate active ongoing inflammation that may promote the osteoclastic/odontoclastic activity associated with FORL.

• Item Type: Articles
• Additional Information: This research was funded by Nestl´e Purina PetCare (St. Louis, MO, USA).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lappin, Dr David and Bennett, Professor David and Riggio, Professor Marcello and Nile, Dr Christopher and Thomas, Sheeba P D R
• Authors: Lappin, D. F., Thomas, S., Bennett, D., Nile, C., and Riggio, M. P.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Research in Veterinary Science
• Publisher: Elsevier
• ISSN: 0034-5288
• ISSN (Online): 1532-2661
• Published Online: 29 November 2023
• Copyright Holders: Copyright: © 2023 The Authors
• First Published: First published in Research in Veterinary Science 166: 105092
• Publisher Policy: Reproduced under a Creative Commons licence