MacKenzie, S. M. , Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C. and Davies, E. (2023) MicroRNAs in aldosterone production and action. In: Vitamins and Hormones. Series: Vitamins and hormones. Elsevier. (doi: 10.1016/bs.vh.2023.07.001) (In Press)
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Abstract
Aldosterone is a cardiovascular hormone with a key role in blood pressure regulation, among other processes, mediated through its targeting of the mineralocorticoid receptor in the renal tubule and selected other tissues. Its secretion from the adrenal gland is a highly controlled process subject to regulatory influence from the renin–angiotensin system and the hypothalamic–pituitary–adrenal axis. MicroRNAs are small endogenous non-coding RNA molecules capable of regulating gene expression post-transcriptionally through stimulation of mRNA degradation or suppression of translation. Several studies have now identified that microRNA levels are changed in cases of aldosterone dysregulation and that microRNAs are capable of regulating the expression of various genes involved in aldosterone production and action. In this article we summarise the major studies concerning this topic. We also discuss the potential role for circulating microRNAs as diagnostic biomarkers for primary aldosteronism, a highly treatable form of secondary hypertension, which would be highly desirable given the current underdiagnosis of this condition.
| Item Type: | Book Sections |
|---|---|
| Additional Information: | L.A.B. is funded by a British Heart Foundation PhD studentship (FS/4yPhD/F/20/34127). S.L. is funded by a PhD studentship through the Medical Research Council Precision Medicine DTP programme (MR/N013166/1). P.R. and M.F. are funded by the European Union’s Horizon 2020 research and innovation programme under the Marie SklodowskaCurie grant agreement No. 954798 (MINDSHIFT ITN), for which M.-C.Z. and E.D. are principal investigators. |
| Status: | In Press |
| Glasgow Author(s) Enlighten ID: | Lamprou, Stelios and Davies, Professor Eleanor and Fayad, May and Rezvanisanijouybari, Ms Parisa and MacKenzie, Dr Scott and Birch, Miss Lara |
| Authors: | MacKenzie, S. M., Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C., and Davies, E. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Publisher: | Elsevier |
| ISSN: | 00836729 |
| Published Online: | 14 August 2023 |
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