Arboleda, L. P. A., de Carvalho, G. B., Santos-Silva, A. R., Fernandes, G. A., Vartanian, J. G., Conway, D. I. , Virani, S., Brennan, P., Kowalski, L. P. and Curado, M. P. (2023) Squamous cell carcinoma of the oral cavity, oropharynx, and larynx: a scoping review of treatment guidelines worldwide. Cancers, 15(17), 4405. (doi: 10.3390/cancers15174405) (PMID:37686681) (PMCID:PMC10486835)
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Abstract
Head and neck cancer (HNC) treatments have been based on single or multimodal therapies with surgery, radiotherapy (RT), chemotherapy, and immunotherapy. However, treatment recommendations among countries may differ due to technological/human resources and usual local practices. This scoping review aims to identify, compare, and map the clinical practice guidelines (CPGs) for treating squamous cell carcinoma (SCC) of the oral cavity, oropharynx, and larynx worldwide. A search strategy on global CPGs for HNC was performed by using five electronic databases and grey literature. CPGs were selected for inclusion using EndNote-20 and Rayyan online software. No language or publication date restrictions were applied. The results were analyzed descriptively considering the most updated CPG version. In total, 25 CPGs covering the head and neck region (10), the larynx (7), the oral cavity (5), and the oropharynx (3), were found in 13 geographical regions, and 19 were developed by medical societies from 1996 to 2023. Surgery and RT remain the main modalities for early-stage HNC, with surgery preferred in low-resource countries, and RT in selected cases, especially in the larynx/oropharynx aiming to achieve a cure with organ preservation. Human papillomavirus infection for oropharyngeal SCC is not tested in some Asian countries and there is still no consensus to treat p16-positive cases differently from p16-negative. Recommendations for larynx preservation vary according to facilities in each country, however, individualized choice is emphasized. Inequality across countries/continents is evident, with a similar pattern of recommendations among developed as well as developing ones. No CPGs were found in Latin America as well as Oceania countries, where the incidence of HNC is high and limitations of access to treatment may be encountered.
| Item Type: | Articles |
|---|---|
| Additional Information: | Financial support: This work was supported by the São Paulo Research Foundation (FAPESP), via a Research Grant—Cooperation Agreements/EU/Horizon 2020—Thematic Research Project: Grant 2018/26297-3, São Paulo Research Foundation (FAPESP). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant No 825771. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Conway, Professor David |
| Authors: | Arboleda, L. P. A., de Carvalho, G. B., Santos-Silva, A. R., Fernandes, G. A., Vartanian, J. G., Conway, D. I., Virani, S., Brennan, P., Kowalski, L. P., and Curado, M. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Cancers |
| Publisher: | MDPI |
| ISSN: | 2072-6694 |
| ISSN (Online): | 2072-6694 |
| Copyright Holders: | Copyright: © 2023 by the authors |
| First Published: | First published in Cancers 15(17): 4405 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
| Data DOI: | 10.17605/OSF.IO/EVFRU |
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