Roth, L. et al. (2023) Pharmacological modulation of vascular ageing: a review from VascAgeNet. Ageing Research Reviews, 92, 102122. (doi: 10.1016/j.arr.2023.102122) (PMID:37956927)
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Abstract
Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.
| Item Type: | Articles |
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| Additional Information: | This paper is based upon work from the European COST ACTION-Network for Research in Vascular Ageing CA18216 supported by COST (European Cooperation in Science and Technology). LR is funded by the Research Council of the University of Antwerp (BOF UAntwerp ID: 45846) and the Fund for Scientific Research (FWO)-Flanders (G060723N). GRYDM and WM are supported by iBOF (Interuniversitair Bijzonder Onderzoeksfonds) ATLANTIS (iBOF-21-053) and the FWO-Flanders (G026723N). AKLH is funded by a National Education Scotland/Chief Scientist Office Clinical Lectureship (PCL/21/05). YS is supported by the Dr. Robert Pfleger Foundation (grant ZUW80298) and the Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Westfälische Wilhelms-Universität, Münster, Germany. FS was supported by NRDIO (FK131946, UNKP-2022), Hungarian Academy of Sciences (BO/00730/19/8). FS and TA are members of the INTEC network. NR has received financial support from Agencia Estatal de Investigación (AEI/10.13039/501100011033) within the Subprograma Ramón y Cajal (RYC-201722879) and CIBERDEM (CB07/08/0016). PM has received financial support from Agence Nationale de la Recherche (ANR-18-CE44-0017). |
| Keywords: | Vascular ageing, endothelial dysfunction, arterial stiffness, drugs, pharmacology, nutrition. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lucas-Herald, Dr Angela |
| Creator Roles: | |
| Authors: | Roth, L., Dogan, S., Tuna, B. G., Aranyi, T., Benitez, S., Borrell-Pages, M., Bozaykut, P., De Meyer, G. R.Y., Duca, L., Durmus, N., Fonseca, D., Fraenkel, E., Gillery, P., Giudici, A., Jaisson, S., Johansson, M., Julve, J., Lucas-Herald, A. K., Martinet, W., Maurice, P., McDonnell, B., Ozbek, E. N., Pucci, G., Pugh, C. J.A., Rochfort, K. D., Roks, A. J.M., Rotllan, N., Shadiow, J., Sohrabi, Y., Spronck, B., Szeri, F., Terentes-Printzios, D., Aydın, E. T., Tura-Ceide, O., Ucar, E., and Anacak, G. Y. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Ageing Research Reviews |
| Publisher: | Elsevier |
| ISSN: | 1568-1637 |
| ISSN (Online): | 1872-9649 |
| Published Online: | 11 November 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Ageing Research Reviews 92:102122 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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