Latent class analyses of multimorbidity and all-cause mortality: A prospective study in Chilean adults

Nazar, G., Díaz-Toro, F., Concha-Cisternas, Y., Leiva-Ordoñez, A. M., Troncoso-Pantoja, C., Celis-Morales, C. and Petermann-Rocha, F. (2023) Latent class analyses of multimorbidity and all-cause mortality: A prospective study in Chilean adults. PLoS ONE, 18(12), e0295958. (doi: 10.1371/journal.pone.0295958) (PMID:38113219) (PMCID:PMC10729966)

Abstract

Multimorbidity patterns can lead to differential risks for all-cause mortality. Within the Chilean context, research on morbidity and mortality predominantly emphasizes individual diseases or combinations thereof, rather than specific disease clusters. This study aimed to identify multimorbidity patterns, along with their associations with mortality, within a representative sample of the Chilean population. 3,701 participants aged ≥18 from the Chilean National Health Survey 2009–2010 were included in this prospective study. Multimorbidity patterns were identified from 16 chronic conditions and then classified using latent class analyses. All-cause mortality data were extracted from the Chilean Civil Registry. The association of classes with all-cause mortality was carried out using Cox proportional regression models, adjusting by sociodemographic and lifestyle variables. Three classes were identified: a) Class 1, the healthiest (72.1%); b) Class 2, the depression/cardiovascular disease/cancer class (17.5%); and c) Class 3, hypertension/chronic kidney disease class (10.4%). Classes 2 and 3 showed higher mortality risk than the healthiest class. After adjusting, Class 2 showed 45% higher mortality risk, and Class 3 98% higher mortality risk, compared with the healthiest class. Hypertension appeared to be a critical underlying factor of all-cause morbidity. Particular combinations of chronic diseases have a higher excess risk of mortality than others.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Celis, Dr Carlos and Petermann-Rocha, Mrs Fanny

Creator Roles

Petermann-Rocha, F.: Conceptualization, Formal analysis, Methodology, Supervision, Writing – review and editing
Celis, C.: Writing – review and editing

• Authors: Nazar, G., Díaz-Toro, F., Concha-Cisternas, Y., Leiva-Ordoñez, A. M., Troncoso-Pantoja, C., Celis-Morales, C., and Petermann-Rocha, F.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Copyright Holders: Copyright: © 2023 Nazar et al.
• First Published: First published in PLoS ONE 18(12): e0295958
• Publisher Policy: Reproduced under a Creative Commons licence