Presentation and outcomes of paediatric craniopharyngioma in the west of Scotland: a 25 year experience

Kuah, X. Y. C. et al. (2024) Presentation and outcomes of paediatric craniopharyngioma in the west of Scotland: a 25 year experience. Journal of Neuro-Oncology, 166(1), pp. 51-57. (doi: 10.1007/s11060-023-04490-5) (PMID:38224403)

Abstract

Purpose: Craniopharyngiomas can be aggressive leading to significant complications and morbidity. It is not clear whether there are any predictive factors for incidence or outcomes. Our aim was therefore to record the incidence, presentation, characteristics and progression of paediatric craniopharyngiomas in the West of Scotland. Method: Retrospective case note review for children diagnosed with paediatric craniopharyngiomas at the Royal Hospital for Children Glasgow, from 1995 to 2021 was conducted. All analyses were conducted using GraphPad Prism 9.4.0. Results: Of 21 patients diagnosed with craniopharyngiomas, the most common presenting symptoms were headaches (17/21, 81%); visual impairment (13/21, 62%); vomiting (9/21, 43%) and growth failure (7/21, 33%). Seventeen (81%) patients underwent hydrocephalus and/or resection surgery within 3 months of diagnosis, usually within the first 2 weeks (13/21, 62%). Subtotal resection surgeries were performed in 71% of patients, and median time between subsequent resection surgeries for tumour recurrence was 4 years (0,11). BMI SDS increased at 5 year follow-up (p = 0.021) with 43% being obese (BMI > + 2SD). More patients acquired hypopituitarism post-operatively (14/16, 88%) compared to pre-operatively (4/15, 27%). A greater incidence of craniopharyngiomas were reported in more affluent areas (10/21, 48%) (SIMD score 8–10) compared to more deprived areas (6/10, 29%) (SIMD score 1–3). Five patients (24%) died with a median time between diagnosis and death of 9 years (6,13). Conclusion: Over 25 years the management of craniopharyngioma has changed substantially. Co-morbidities such as obesity are difficult to manage post-operatively and mortality risk can be up to 25% according to our cohort.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Millar, Dr Eoghan and O'Kane, Mr Roddy and Sastry, Dr Jairam and Murphy, Dr Dermot and Dorris, Professor Liam and Amato-Watkins, Mr Anthony and Adey, Claire and Shaikh, Dr Mohammed Guftar and Ronghe, Dr Milind and Hassan, Mr Samih and McCarrison, Dr Sarah and Fulton, Ben and Lucas-Herald, Dr Angela and Campbell, Miss Emer
• Authors: Kuah, X. Y. C., Lucas-Herald, A. K., McCarrison, S., Boyle, R., Adey, C., Amato-Watkins, A., Bhattathiri, P., Campbell, E., Cowie, F., Dorris, L., Fulton, B., Mcintosh, D., Murphy, D., Ronghe, M., O'Kane, R., Todd, L., Sangra, M., Sastry, J., Millar, E., Hassan, S., and Shaikh, M. G.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Neuro-Oncology
• Publisher: Springer
• ISSN: 0167-594X
• ISSN (Online): 1573-7373
• Published Online: 15 January 2024