Special patient populations: transplant recipients

Kobashigawa, J. A., FellstrÖm, B., Mark, P. B. and Jardine, A. G. (2023) Special patient populations: transplant recipients. In: Ballantyne, C. M. (ed.) Clinical Lipidology: A Companion to Braunwald's Heart Disease [3rd ed.]. Series: Companion to Braunwald's Heart Disease series. Elsevier, 358-366.e2. ISBN 9780323882866 (doi: 10.1016/B978-0-323-88286-6.00037-6)

Abstract

Solid organ transplantation as a treatment for kidney, liver, or heart failure increases both duration and quality of life. Cardiovascular disease is a leading cause of death for recipients of all these organs, and for renal transplant recipients, patient death is a leading cause of transplant loss. Immunosuppressive therapy with corticosteroids, calcineurin inhibitors, and/or proliferation signal inhibitors contributes to the pattern of dyslipidemia seen in transplant recipients. Although statin therapy has been demonstrated to lower low-density lipoprotein cholesterol in transplant recipients in a similar manner as in nontransplant populations, pharmacokinetic interactions with immunosuppressive therapy impact both choice and dose of lipid-lowering agents.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Mark, Professor Patrick and Jardine, Professor Alan
• Authors: Kobashigawa, J. A., FellstrÖm, B., Mark, P. B., and Jardine, A. G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Publisher: Elsevier
• ISBN: 9780323882866