McDowell, K., Adamson, C., Jackson, C., Campbell, R., Welsh, P. , Petrie, M. C. , McMurray, J. J.V. , Jhund, P. and Herring, N. (2023) Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes. European Journal of Heart Failure, (doi: 10.1002/ejhf.3085) (PMID:37937329) (Early Online Publication)
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Abstract
Aims: Neuropeptide Y (NPY) is the most abundant neuropeptide found in the heart and is released alongside norepinephrine following prolonged sympathetic activation, a process that is implicated in the pathophysiology of heart failure (HF). In patients with severely impaired left ventricular ejection fraction (LVEF) undergoing cardiac resynchronization therapy, higher levels of NPY measured in coronary sinus blood, are associated with poorer outcome. The aim was to examine the association of peripheral venous NPY levels and outcomes in a HF population with a range of LVEF, using a highly sensitive and specific assay. Methods and results: The association between NPY and the composite outcome of cardiovascular death or HF hospitalization, its components, and all-cause mortality was examined using Cox regression analyses among 833 patients using a threshold of elevated NPY identified through binary recursive partitioning adjusted for prognostic variables including estimated glomerular filtration rate (eGFR), ejection fraction and B-type natriuretic peptide (BNP). The mean value of NPY was 25.8 ± 18.2 pg/ml. Patients with high NPY levels (≥29 pg/ml) compared with low values were older (73 ± 10 vs. 71 ± 11 years), more often male (58.5% vs. 55.6%), had higher BNP levels (583 [261–1096] vs. 440 [227–829] pg/ml), lower eGFR (46.4 ± 13.9 vs. 52.4 ± 11.7 ml/min/1.73 m2), and were more often treated with diuretics. There was no associated risk of HF hospitalization with NPY levels ≥29 vs. <29 pg/ml. Higher NPY levels were associated with a greater risk of cardiovascular and all-cause death (adjusted hazard ratio 1.56 [95% confidence interval 1.21–2.10], p = 0.003 and 1.30 [1.04–1.62], p = 0.02, respectively). There was no associated risk of HF hospitalization with higher NPY levels. Conclusions: Peripherally measured NPY is an independent predictor of all-cause and cardiovascular death even after adjustment for other prognostic variables, including BNP.
| Item Type: | Articles |
|---|---|
| Additional Information: | The study was supported by a British Heart Foundation Senior ClinicalResearch Fellowship (FS/SCRF/20/32005) to Neil Herring and the BHFOxford Centre of Research Excellence (RE/13/1/30181). Carly Adamson,Mark C. Petrie, John J.V. McMurray and Pardeep S. Jhund are supportedby a British Heart Foundation Centre of Research Excellence Grant(RE/18/6/34217) and the Vera Melrose Heart Failure Research Fund.Ross Campbell was supported by a project grant from the British HeartFoundation; Grant number PG/13/17/30050. |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adamson, Dr Carly and McDowell, Dr Kirsty and Jhund, Professor Pardeep and Welsh, Professor Paul and Campbell, Dr Ross and McMurray, Professor John and Petrie, Professor Mark |
| Authors: | McDowell, K., Adamson, C., Jackson, C., Campbell, R., Welsh, P., Petrie, M. C., McMurray, J. J.V., Jhund, P., and Herring, N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | European Journal of Heart Failure |
| Publisher: | Wiley |
| ISSN: | 1388-9842 |
| ISSN (Online): | 1879-0844 |
| Published Online: | 08 November 2023 |
| Copyright Holders: | Copyright © 2023 The Authors. |
| First Published: | First published in European Journal of Heart Failure 2023 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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