Down-regulation of MHC class I is a property common to papillomavirus E5 proteins

Ashrafi, G.H., Brown, D.R., Fife, K.H. and Campo, M.S. (2006) Down-regulation of MHC class I is a property common to papillomavirus E5 proteins. Virus Research, 120(1-2), pp. 208-211. (doi: 10.1016/j.virusres.2006.02.005)



Publisher's URL:


The E5 protein family of papillomaviruses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear. We have reported that the E5 proteins of BPV-1, BPV-4, HPV-16 and HPV-6 down-regulate MHC class I, potentially helping the virus evade the host immune response. Others have described MHC class I down-regulation by HPV-2 E5. We report here that another E5 protein, HPV-83 E5, likewise down-regulates MHC class I and propose that interference with expression, assembly and/or transport of MHC class I is a common property of all E5 proteins evolved by the virus to circumvent host immunosurveillance and thus establish productive infection.

Item Type:Articles
Keywords:HPV-83; E5; MHC class I down-regulation; E5-heavy chain interaction
Glasgow Author(s) Enlighten ID:Ashrafi, Dr Gholam Hossein and Campo, Professor Saveria
Authors: Ashrafi, G.H., Brown, D.R., Fife, K.H., and Campo, M.S.
Subjects:Q Science > QR Microbiology > QR180 Immunology
S Agriculture > SF Animal culture > SF600 Veterinary Medicine
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Virus Research
Publisher:Elsevier Science
Copyright Holders:Copyright © 2006 Elsevier Science
First Published:First published in Virus Research 120(1-2):208-211
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record