The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I

Araibi, E.H., Marchetti, B., Dornan, E.S., Ashrafi, G.H., Dobromylskyj, D., Ellis, S.A. and Campo, M.S. (2006) The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I. Virology, 353(1), pp. 174-183. (doi: 10.1016/j.virol.2006.05.031)

Abstract

The major histocompatibility complex (MHC) class I region in mammals contains both classical and non-classical MHC class I genes. Classical MHC class I molecules present antigenic peptides to cytotoxic T lymphocytes, whereas non-classical MHC class I molecules have a variety of functions. Both classical and non-classical MHC molecules interact with natural killer cell receptors and may under some circumstances prevent cell death by natural killer cytotoxicity. The E5 oncoprotein of BPV-4 down-regulates the expression of classical MHC class I on the cell surface and retains the complex in the Golgi apparatus. The inhibition of classical MHC class I to the cell surface results from both the impaired acidification of the Golgi, due to the interaction of E5 with subunit c of the H+ V-ATPase, and to the physical binding of E5 to the heavy chain of MHC class I. Despite the profound effect of E5 on classical MHC class I, E5 does not retain a non-classical MHC class I in the Golgi, does not inhibit its transport to the cell surface and does not bind its heavy chain. We conclude that, as is the case for HPV-16 E5, BPV-4 E5 does not down-regulate certain non-classical MHC class I, potentially providing a mechanism for the escape of the infected cell from attack by both cytotoxic T lymphocytes and NK cells.

• Item Type: Articles
• Keywords: BPV; E5; Classical MHC class I; Non-classical MHC class I; E5-MHC class I interaction; MHC class I down-regulation
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ashrafi, Dr Gholam Hossein and Campo, Professor Saveria and Marchetti, Dr Barbara and Dornan, Mr Edward
• Authors: Araibi, E.H., Marchetti, B., Dornan, E.S., Ashrafi, G.H., Dobromylskyj, D., Ellis, S.A., and Campo, M.S.
• Subjects: Q Science > QR Microbiology > QR180 Immunology; S Agriculture > SF Animal culture > SF600 Veterinary Medicine
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Virology
• Publisher: Elsevier Science
• ISSN: 1096-0341
• Copyright Holders: Copyright © 2006 Elsevier Science
• First Published: First published in Virology 353(1):174-183
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher