Brum, W. S., Docherty, K. F. , Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V. and Blennow, K. (2023) Effect of neprilysin inhibition on Alzheimer disease plasma biomarkers: a secondary analysis of a randomized clinical trial. JAMA Neurology, (doi: 10.1001/jamaneurol.2023.4719) (PMID:38109077) (PMCID:PMC10728797) (Early Online Publication)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
308026.pdf - Published Version Available under License Creative Commons Attribution. 274kB |
|
Text
308026_Suppl.pdf - Accepted Version 246kB |
Abstract
Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronary heart disease.
| Item Type: | Articles (Letter) |
|---|---|
| Additional Information: | The trial on which this exploratory analysis is based was funded by grant PG/17/23/32850 from the British Heart Foundation. This study was supported by grant RE/18/6/34217 from the British Heart Foundation Centre of Research Excellence Grant (Dr McMurray); grants 2022-01018 and 2019-02397 from the Swedish Research Council, grant 101053962 from the European Union’s Horizon Europe Research and Innovation Programme, grant ALFGBG-71320 from Swedish State Support for Clinical Research, grant 201809-2016862 from the Alzheimer Drug Discovery Foundation USA, grants ADSF-21-831376-C, ADSF-21-831381-C, and ADSF-21-831377-C from the Alzheimer’s Disease Strategic Fund and Alzheimer’s Association, the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, grant FO2022-0270 from the Stiftelsen för Gamla Tjänarinnor, Marie Skłodowska-Curie grant agreement 860197 from the European Union’s Horizon 2020 Research and Innovation Programme, grant JPND2021-00694 from the European Union Joint Programme–Neurodegenerative Disease Research, and grant UKDRI-1003 from the UK Dementia Research Institute at University College London (Dr Zetterberg); grant 2022-00775 from the Swedish Research Council; grant ERAPERMED2021-184 from ERA PerMed, grant 2017-0383 from the Knut and Alice Wallenberg Foundation, the Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson’s disease) at Lund University, grant AF-980907 from the Swedish Alzheimer Foundation, grant FO2021-0293 from the Swedish Brain Foundation, grant 1412/22 from the Parkinson Foundation of Sweden, the Cure Alzheimer’s Fund, the Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, grant 2020-O000028 from the Skåne University Hospital Foundation, grant 2022-1259 from the Regionalt Forskningsstöd, and grant 2022-Projekt0080 from the Swedish federal government under the ALF agreement (Lund University); grants 88887.372371/ 2019-00 and 88887.596742/2020-00 from CAPES and the Stiftelsen för Gamla Tjänarinnor (Mr Brum); and grants 2017-00915 from the Swedish Research Council, RDAPB-201809-2016615 from the Alzheimer’s Drug Discovery Foundation, AF-742881 from the Swedish Alzheimer Foundation, FO2017-0243 from Hjärnfonden, Sweden, ALFGBG-715986 from the Swedish state under agreement between the Swedish government and the County Councils, the Avtal om Läkarutbildning och Forskining agreement, JPND2019-466-236 from the European Union Joint Programme for Neurodegenerative Disorders, and 1R01AG068398-01 from the National Institutes of Health (Prof Blennow). |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Docherty, Dr Kieran and McMurray, Professor John |
| Authors: | Brum, W. S., Docherty, K. F., Ashton, N. J., Zetterberg, H., Hansson, O., McMurray, J. J. V., and Blennow, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | JAMA Neurology |
| Publisher: | American Medical Association |
| ISSN: | 2168-6149 |
| ISSN (Online): | 2168-6157 |
| Published Online: | 18 December 2023 |
| Copyright Holders: | Copyright © 2023 Brum WS et al. |
| First Published: | First published in JAMA Neurology 2023 |
| Publisher Policy: | Reproduced under a Creative Commons license |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information