Campillo Poveda, M. , Britton, C. , Devaney, E. , McNeilly, T. N., Gerbe, F., Jay, P. and Maizels, R. M. (2023) Tuft cells: detectors, amplifiers, effectors and targets in parasite infection. Cells, 12(20), 2477. (doi: 10.3390/cells12202477) (PMID:37887321) (PMCID:PMC10605326)
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Abstract
Tuft cells have recently emerged as the focus of intense interest following the discovery of their chemosensory role in the intestinal tract, and their ability to activate Type 2 immune responses to helminth parasites. Moreover, they populate a wide range of mucosal tissues and are intimately connected to immune and neuronal cells, either directly or through the release of pharmacologically active mediators. They are now recognised to fulfil both homeostatic roles, in metabolism and tissue integrity, as well as acting as the first sensors of parasite infection, immunity to which is lost in their absence. In this review we focus primarily on the importance of tuft cells in the intestinal niche, but also link to their more generalised physiological role and discuss their potential as targets for the treatment of gastrointestinal disorders.
Item Type: | Articles |
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Additional Information: | This research was funded by the Wellcome Trust through a Collaborative Award to CB, ED, PJ, TMcN, and RMM (Ref 211814), who also funded the APC. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mcneilly, Dr Tom and Devaney, Professor Eileen and Campillo Poveda, Dr Marta and Britton, Professor Collette and Maizels, Professor Rick |
Authors: | Campillo Poveda, M., Britton, C., Devaney, E., McNeilly, T. N., Gerbe, F., Jay, P., and Maizels, R. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Cells |
Publisher: | MDPI |
ISSN: | 2073-4409 |
ISSN (Online): | 2073-4409 |
Copyright Holders: | Copyright © 2023 by the authors |
First Published: | First published in Cells 12(20):2477 |
Publisher Policy: | Reproduced under a Creative Commons license |
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