ISCEV standard pattern reversal VEP development: paediatric reference limits from 649 healthy subjects

Thompson, D. A., Mikó-Baráth, E., Hardy, S. E., Jandó, G., Shaw, M. and Hamilton, R. (2023) ISCEV standard pattern reversal VEP development: paediatric reference limits from 649 healthy subjects. Documenta Ophthalmologica, 147, pp. 147-164. (doi: 10.1007/s10633-023-09952-9) (PMID:37938426) (PMCID:PMC10638119)

Abstract

Purpose: To establish the extent of agreement for ISCEV standard reference pattern reversal VEPs (prVEPs) acquired at three European centres, to determine any effect of sex, and to establish reference intervals from birth to adolescence. Methods: PrVEPs were recorded from healthy reference infants and children, aged 2 weeks to 16 years, from three centres using closely matched but non-identical protocols. Amplitudes and peak times were modelled with orthogonal quadratic and sigmoidal curves, respectively, and two-sided limits, 2.5th and 97.5th centiles, estimated using nonlinear quantile Bayesian regression. Data were compared by centre and by sex using median quantile confidence intervals. The ‘critical age’, i.e. age at which P100 peak time ceased to shorten, was calculated. Results: Data from the three centres were adequately comparable. Sex differences were not clinically meaningful. The pooled data showed rapid drops in P100 peak time which stabilised by 27 and by 34 weeks for large and small check widths, respectively. Post-critical-age reference limits were 87–115 ms and 96–131 ms for large and small check widths, respectively. Amplitudes varied markedly and reference limits for all ages were 5–57 μV and 3.5–56 μV for large and small check widths, respectively. Conclusions: PrVEP reference data could be combined despite some methodology differences within the tolerances of the ISCEV VEP Standard, supporting the clinical benefit of ISCEV Standards. Comparison with historical data is hampered by lack of minimum reporting guidelines. The reference data presented here could be validated or transformed for use elsewhere.

• Item Type: Articles
• Additional Information: This work was partly funded by grants from the R.S. Macdonald Charitable Trust; the Chief Scientist Office (Scotland) Grant K/RED/4/C279; The Ulverscroft Foundation; The Nuffield Foundation (for RH); Hungarian Brain Research Program 2.0 (NAP 2.0); Thematic Excellence Program 2021 Health Sub-programme of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of the Pécs of University (TKP2021-EGA-16) (for EMB and GJ).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hamilton, Dr Ruth and Shaw, Dr Martin
• Authors: Thompson, D. A., Mikó-Baráth, E., Hardy, S. E., Jandó, G., Shaw, M., and Hamilton, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Documenta Ophthalmologica
• Publisher: Springer
• ISSN: 0012-4486
• ISSN (Online): 1573-2622
• Published Online: 08 November 2023
• Copyright Holders: Copyright © The Author(s) 2023
• First Published: First published in Documenta Ophthalmologica 147: 147–164
• Publisher Policy: Reproduced under a Creative Commons license