A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials

Ciani, O. et al. (2023) A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials. EClinicalMedicine, 65, 102283. (doi: 10.1016/j.eclinm.2023.102283) (PMID:37877001) (PMCID:PMC10590868)

[img] Text
307890.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.



Background Interventional trials that evaluate treatment effects using surrogate endpoints have become increasingly common. This paper describes four linked empirical studies and the development of a framework for defining, interpreting and reporting surrogate endpoints in trials. Methods As part of developing the CONSORT (Consolidated Standards of Reporting Trials) and SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) extensions for randomised trials reporting surrogate endpoints, we undertook a scoping review, e-Delphi study, consensus meeting, and a web survey to examine current definitions and stakeholder (including clinicians, trial investigators, patients and public partners, journal editors, and health technology experts) interpretations of surrogate endpoints as primary outcome measures in trials. Findings Current surrogate endpoint definitional frameworks are inconsistent and unclear. Surrogate endpoints are used in trials as a substitute of the treatment effects of an intervention on the target outcome(s) of ultimate interest, events measuring how patients feel, function, or survive. Traditionally the consideration of surrogate endpoints in trials has focused on biomarkers (e.g., HDL cholesterol, blood pressure, tumour response), especially in the medical product regulatory setting. Nevertheless, the concept of surrogacy in trials is potentially broader. Intermediate outcomes that include a measure of function or symptoms (e.g., angina frequency, exercise tolerance) can also be used as substitute for target outcomes (e.g., all-cause mortality)—thereby acting as surrogate endpoints. However, we found a lack of consensus among stakeholders on accepting and interpreting intermediate outcomes in trials as surrogate endpoints or target outcomes. In our assessment, patients and health technology assessment experts appeared more likely to consider intermediate outcomes to be surrogate endpoints than clinicians and regulators. Interpretation There is an urgent need for better understanding and reporting on the use of surrogate endpoints, especially in the setting of interventional trials. We provide a framework for the definition of surrogate endpoints (biomarkers and intermediate outcomes) and target outcomes in trials to improve future reporting and aid stakeholders' interpretation and use of trial surrogate endpoint evidence.

Item Type:Articles
Additional Information:Funding: SPIRIT-SURROGATE/CONSORT-SURROGATE project is Medical Research Council Better Research Better Health (MR/V038400/1) funded.
Keywords:Surrogate endpoints, target outcomes, intermediate outcomes.
Glasgow Author(s) Enlighten ID:Ciani, Professor Oriana and Manyara, Dr Anthony and Taylor, Professor Rod
Authors: Ciani, O., Manyara, A. M., Davies, P., Stewart, D., Weir, C. J., Young, A. E., Blazeby, J., Butcher, N. J., Bujkiewicz, S., Chan, A.-w., Dawoud, D., Offringa, M., Ouwens, M., Hróbjartssson, A., Amstutz, A., Bertolaccini, L., Bruno, V. D., Devane, D., Faria, C. D., Gilbert, P. B., Harris, R., Lassere, M., Marinelli, L., Markham, S., Powers, J. H., Rezaei, Y., Richert, L., Schwendicke, F., Tereshchenko, L. G., Thoma, A., Turan, A., Worrall, A., Christensen, R., Collins, G. S., Ross, J. S., and Taylor, R. S.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
Journal Name:EClinicalMedicine
ISSN (Online):2589-5370
Published Online:16 October 2023
Copyright Holders:Copyright: © 2023 The Author(s)
First Published:First published in EClinicalMedicine 65: 102283
Publisher Policy:Reproduced under a Creative Commons licence

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
313399Reporting of randomised trials using surrogate outcomes: development of extensions to the CONSORT 2010 and SPIRIT 2013 guidance statementsRodney Stephen TaylorMedical Research Council (MRC)MR/V038400/1SHW - MRC/CSO Social & Public Health Sciences Unit