A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

Sri, S. et al. (2023) A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia. Cerebral Circulation - Cognition and Behavior, 5, 100189. (doi: 10.1016/j.cccb.2023.100189) (PMID:37941765) (PMCID:PMC10628644)

Abstract

Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

• Item Type: Articles
• Additional Information: The workshop upon which this paper was based was supported by the UK Dementia Research Institute, Dementia Platforms UK (DPUK1: MRC grant MR/L023784/2: UK Dementias Research Platform; DPUK2: MRC grant MR/T033371/1: MICA: Dementias Platform UK 2 – Integrated Dementia Experimental Medicine), British Heart Foundation and Guarantors of Brain. The UK Dementia Research Institute receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Goense, Dr Jozien and Moss, Professor Jonathan and Work, Dr Lorraine and Quinn, Professor Terry and Brezzo, Dr Gaia and Leiper, Professor James
• Authors: Sri, S., Greenstein, A., Granata, A., Collcutt, A., Jochems, A. C.C., McColl, B. W., Díaz Castro, B., Webber, C., Arteaga Reyes, C., Hall, C., Lawrence, C. B., Hawkes, C., Pegasiou-Davies, C.-M., Gibson, C., Crawford, C., Smith, C., Vivien, D., McLean, F. H., Wiseman, F., Brezzo, G., Lalli, G., Pritchard, H. A.T., Markus, H. S., Bravo-Ferrer, I., Taylor, J., Leiper, J., Berwick, J., Gan, J., Gallacher, J., Moss, J., Goense, J., McMullan, L., Work, L., Evans, L., Stringer, M. S., Ashford, M.L.J., Abulfadl, M., Conlon, N., Malhotra, P., Bath, P., Canter, R., Brown, R., Ince, S., Anderle, S., Young, S., Quick, S., Szymkowiak, S., Hill, S., Allan, S., Wang, T., Quinn, T., Procter, T., Farr, T. D., Zhao, X., Yang, Z., Hainsworth, A. H., and Wardlaw, J. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Cerebral Circulation - Cognition and Behavior
• Publisher: Elsevier
• ISSN: 2666-2450
• ISSN (Online): 2666-2450
• Published Online: 11 October 2023
• Copyright Holders: Copyright: © 2023 The Authors
• First Published: First published in Cerebral Circulation - Cognition and Behavior 5:100189
• Publisher Policy: Reproduced under a Creative Commons licence