Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)

Anthon, C. T. et al. (2023) Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU). Intensive Care Medicine, (doi: 10.1007/s00134-023-07225-2) (PMID:37812225) (Early Online Publication)

Abstract

Purpose: Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. Methods: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses. Results: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4–46.1) had thrombocytopenia; 23.4% (20–26) had thrombocytopenia at ICU admission, and 19.8% (17.6–22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19–2.42). Conclusion: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.

• Item Type: Articles
• Additional Information: Open access funding provided by Royal Library, Copenhagen University Library. This study was funded by the Research Council of Rigshospitalet, the Ehrenreich’s Foundation, and the Dagmar Marshalls Foundation. The Memorial Sloan Kettering Cancer Center part of the study was supported by the Core Grant, Grant/Award Number: P30CA008748; Department of Anaesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Keywords: Thrombocytopenia, platelet transfusion, critical illness, intensive care unit, bleeding, thrombosis.
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Puxty, Dr Kathryn
• Authors: Anthon, C. T., Pène, F., Perner, A., Azoulay, E., Puxty, K., Louw, A. V. D., Barratt-Due, A., Chawla, S., Castro, P., Povoa, P., Coelho, L., Metaxa, V., Kochanek, M., Liebregts, T., Kander, T., Hästbacka, J., Bønding Andreasen, J., Péju, E., Nielsen, L. B., Hvas, C. L., Dufranc, E., Canet, E., Lundqvist, L., Wright, C. J., Schmidt, J., Uhel, F., Ait-Oufella, H., Krag, M., Cos Badia, E., Lagares, C. D., Menat, S., Voiriot, G., Clausen, N. E., Lorentzen, K., Kvåle, R., Hildebrandt, T., Holten, A. R., Strand, K., Tzalavras, A., Bestle, M. H., Klepstad, P., Fernandez, S., Vimpere, D., Paulino, C., Graça, C., Lueck, C., Juhl, C. S., Costa, C., Bådstøløkken, P. M., Miranda, T., Lêdo, L. S. A., Torres, J. C. S., Granholm, A., Møller, M. H., and Russell, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Intensive Care Medicine
• Publisher: Springer
• ISSN: 0342-4642
• ISSN (Online): 1432-1238
• Published Online: 09 October 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Intensive Care Medicine 2023
• Publisher Policy: Reproduced under a Creative Commons License