Charge dynamics of amino acids fingerprints and the effect of density on FinFET-based electrolyte-gated sensor

Kumar, N. , Pascual García, C., Dixit, A., Rezaei, A. and Georgiev, V. (2023) Charge dynamics of amino acids fingerprints and the effect of density on FinFET-based electrolyte-gated sensor. Solid-State Electronics, 210, 108789. (doi: 10.1016/j.sse.2023.108789)

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This work presents the charge dynamics and the effect of the density of amino acids on a sensing surface with the help of analytical modelling. We have implemented an in-house simulator incorporating the Gouy-Chapman-Stern and Site-Binding model to capture the perturbations in the proton affinity of reactive sites with the variation of amino acid density over a sensing surface. The results of the models are explained for Alanine, Glutamic Acid and Histidine with their α-carboxylic terminal immobilized on the sensor surface. The results show that an increase in amino acid density on the sensing surface over a certain limit deviates the fingerprints of the proton affinity away from the affinity of the reactive sites of individual amino acids. The effect of different electrolyte concentrations on steric hindrance is also captured for Alanine and Glutamic Acid. Finally, we used a junctionless FinFET to model unique signatures of amino acids down to a single molecule.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dixit, Mr Ankit and Rezaei, Dr Ali and Kumar, Dr Naveen and Georgiev, Professor Vihar
Authors: Kumar, N., Pascual García, C., Dixit, A., Rezaei, A., and Georgiev, V.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Solid-State Electronics
ISSN (Online):1879-2405
Published Online:06 October 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Solid-State Electronics 210:108789
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
305900Electrochemically-enabled high-throughput peptidomics for next-generation precision medicineVihar GeorgievEuropean Commission (EC)862539ENG - Electronics & Nanoscale Engineering