Revisiting the roles of cAMP signalling in the progression of prostate cancer

Parsons, E. C. , Baillie, G. S. and Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480(20), pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Abstract

Prostate cancer is one of the most common cancers in men and one of the top causes of death in men worldwide. Development and function of both normal prostate cells and early-stage prostate cancer cells are dependent on the cross-talk between androgen signalling systems and a variety of other transduction pathways which drive differentiation of these cells towards castration-resistance. One such signalling pathway is the ubiquitous cAMP signalling axis which functions to activate spatially restricted pools of cAMP effectors such as protein kinase A (PKA). The importance of both PKA and cAMP in the development of prostate cancer, and their interactions with the androgen receptor, were the focus of a review by Merkle and Hoffmann in 2010. In this updated review, we revisit this topic with analysis of current PKA-related prostate cancer literature and introduce novel information on the relevance of another cAMP effector, the exchange protein directly activated by cAMP (EPAC).

• Item Type: Articles
• Additional Information: This work was supported by an MRC iCASE PhD award to G.S.B. and E.C.P.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Parsons, Miss Emma and Baillie, Professor George and Hoffmann, Dr Ralf

Creator Roles

Baillie, G. S.: Conceptualization, Writing – review and editing
Parsons, E. C.: Conceptualization, Writing – original draft, Writing – review and editing
Hoffmann, R.: Conceptualization, Writing – original draft, Writing – review and editing

• Authors: Parsons, E. C., Baillie, G. S., and Hoffmann, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Biochemical Journal
• Publisher: Portland Press
• ISSN: 0264-6021
• ISSN (Online): 1470-8728
• Published Online: 13 October 2023
• Copyright Holders: Copyright © 2023 The Author(s).
• First Published: First published in Biochemical Journal 480(20):1599-1614
• Publisher Policy: Reproduced under a Creative Commons license