Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L. and Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Research and Clinical Practice, 204, 110929. (doi: 10.1016/j.diabres.2023.110929) (PMID:37783345)
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Abstract
Aims: To compare maternal and fetal cord plasma and lipoprotein triglyceride (TG) concentrations in women with Gestational Diabetes Mellitus (GDM), with hyperglycaemia and hypertriglyceridaemia, and healthy women. Methods: Fasted maternal blood at 28.6 ± 3.4 (T1) and 36.2 ± 1.0 (T2) [mean ± S.D] weeks of gestation, and cord blood were collected. Plasma lipoprotein fractions underwent compositional analysis. Results: Plasma glucose did not differ between GDM and healthy women. T1 maternal plasma TG (2.60 ± 0.89 mmol/l versus 1.71 ± 0.69 mmol/l) and plasma apolipoprotein B (1.30 ± 0.48 g/l versus 0.75 ± 0.40 g/l) were higher in GDM compared to healthy. Maternal plasma TG increased over gestation in both groups. T1 plasma VLDL total protein (38 ± 15 mg/dl versus 25 ± 11 mg/dl), total cholesterol (TC) (30 ± 14 mg/dl versus 16 ± 13 mg/dl) and phospholipid (PL) (43 ± 17 mg/dl versus 26 ± 16 mg/dl) were higher in GDM than healthy, and similarly for IDL, suggesting increased lipoprotein particle number. T1 VLDL-TG enrichment was higher in healthy and increased over gestation in GDM women but decreased in healthy. IDL-TG enrichment (TG/TC) increased over gestation in women with GDM and decreased in healthy. Cord blood VLDL, IDL and LDL from GDM had a two-fold higher TG enrichment than healthy pregnancy. Conclusion: Increased maternal lipoprotein number, but not TG enrichment, in GDM mothers may explain TG enrichment of cord lipoproteins.
Item Type: | Articles |
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Additional Information: | This research was funded by the Royal Brisbane and Women’s Hospital Foundation $19,544; the University of Wollongong, Faculty of Science Medicine and Health, Small Grant $16,000 2021 and a Wellbeing of Women Research Training, Fellowship RTF 203 (E. Jarvie). |
Keywords: | Gestational Diabetes Mellitus, hypertriglyceridaemia, maternal lipoproteins, cord lipoproteins, cord lipoprotein triglyceride enrichment. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Freeman, Dr Dilys |
Creator Roles: | |
Authors: | Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L., and Freeman, D. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Diabetes Research and Clinical Practice |
Publisher: | Elsevier |
ISSN: | 0168-8227 |
ISSN (Online): | 0168-8227 |
Published Online: | 30 September 2023 |
Copyright Holders: | Copyright © 2023 Elsevier B.V |
First Published: | First published in Diabetes Research and Clinical Practice 204:110929 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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