Recent developments in frailty identification, management, risk factors and prevention: a narrative review of leading journals in geriatrics and gerontology

Dent, E. et al. (2023) Recent developments in frailty identification, management, risk factors and prevention: a narrative review of leading journals in geriatrics and gerontology. Ageing Research Reviews, 91, 102082. (doi: 10.1016/j.arr.2023.102082) (PMID:37797723)

[img] Text
307653.pdf - Published Version
Available under License Creative Commons Attribution.



Frailty is an age-related clinical condition characterised by an increased susceptibility to stressors and an elevated risk of adverse outcomes such as mortality. In the light of global population ageing, the prevalence of frailty is expected to soar in coming decades. This narrative review provides critical insights into recent developments and emerging practices in frailty research regarding identification, management, risk factors, and prevention. We searched journals in the top two quartiles of geriatrics and gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 and 20 December 2022. Several recent developments were identified, including new biomarkers and biomarker panels for frailty screening and diagnosis, using artificial intelligence to identify frailty, and investigating the altered response to medications by older adults with frailty. Other areas with novel developments included exercise (including technology-based exercise), multidimensional interventions, person-centred and integrated care, assistive technologies, analysis of frailty transitions, risk-factors, clinical guidelines, COVID-19, and potential future treatments. This review identified a strong need for the implementation and evaluation of cost-effective, community-based interventions to manage and prevent frailty. Our findings highlight the need to better identify and support older adults with frailty and involve those with frailty in shared decision-making regarding their care.

Item Type:Articles
Additional Information:On behalf of the EPI-FRAIL consortium. The Frailty Epidemiology Research Network (EPI-FRAIL) is an international collaborative project aimed at filling knowledge gaps in the field of frailty epidemiology. The network was established as part of a NWO/ZonMw Veni fellowship awarded to E.O. Hoogendijk (Grant no. 91618067). P. Hanlon is funded through a Clinical Research Training Fellowship from the Medical Research Council (Grant reference: MR/S021949/1). Z. Liu was supported by the Soft Science Research Program of Zhejiang Province (2023KXCX-KT011). J. Jylhävä has received grant support from the Swedish Research Council (grant no. 2018–02077), the Academy of Finland (grant no. 349335), the Sigrid Jusélius Foundation, the Yrjö Jahnsson Foundation and the Instrumentarium Science Foundation. M. Sim is supported by a Royal Perth Hospital Research Foundation Career Advancement Fellowship and an Emerging Leader Fellowship from the Future Health Research and Innovation Fund (Department of Health, Western Australia). R. Ambagtsheer receives funding from the Australian Medical Research Future Fund (grant #MRF2016140). D. Liborio Vetrano receives financial support from the Swedish Research Council (2021-03324). S. Shi reports funding from the National Institute of Aging, R03AG078894-01.
Keywords:Frailty, aged, biomarkers, risk factors, geriatric assessment.
Glasgow Author(s) Enlighten ID:Hanlon, Dr Peter
Authors: Dent, E., Hanlon, P., Sim, M., Jylhävä, J., Liu, Z., Vetrano, D. L., Stolz, E., Pérez-Zepeda, M. U., Crabtree, D., Nicholson, C., Job, J., Ambagtsheer, R. C., Ward, P. R., Shi, S. M., Huynh, Q., and Hoogendijk, E. O.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
Journal Name:Ageing Research Reviews
ISSN (Online):1872-9649
Published Online:04 October 2023
Copyright Holders:Copyright © 2023 The Author(s)
First Published:First published in Ageing Research Reviews 91:102082
Publisher Policy:Reproduced under a Creative Commons license

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
305232Understanding prevalence and impact of frailty in chronic illness and implications for clinical managementFrances MairMedical Research Council (MRC)MR/S021949/1SHW - General Practice & Primary Care