Cardiac abnormalities in patients with severe fever with thrombocytopenia syndrome: a systematic review

Liu, Q., Yang, M., Shen, S., Gong, C. and Lan, Z. (2023) Cardiac abnormalities in patients with severe fever with thrombocytopenia syndrome: a systematic review. Open Forum Infectious Diseases, 10(11), ofad509. (doi: 10.1093/ofid/ofad509) (PMID:37937042) (PMCID:PMC10627340)

Abstract

Since the identification of severe fever with thrombocytopenia syndrome virus (SFTSV) in 2010, there has been an increase in reported cases in China and other Asian countries. Cardiac abnormalities are highly prevalent in SFTS patients. We searched 5 Chinese and international databases for published SFTS articles and extracted patient characteristics, cardiac complications, electrocardiography findings, and imaging findings. Twenty-seven studies were identified, covering 1938 patients and 621 cardiac abnormalities. Arrhythmia was the most prevalent, reported in 24 studies and 525 cases, with a prevalence of 27.09%. The 2 major types of arrhythmias were bradycardia and atrial fibrillation. Heart failure was the second most prevalent abnormality, with 77 cases. Changes in the ST segment and T wave were the most common. Valve regurgitation, reduced ejection fraction, and pericardial effusion were also documented. We recommend that physicians pay close attention to newly onset arrhythmia and structural heart disease in SFTS patients.

• Item Type: Articles
• Keywords: Cardiac abnormality, human, severe fever with thrombocytopenia syndrome.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liu, Qiaoling and Yang, Dr Mingming

Creator Roles

Liu, Q.: Conceptualization, Methodology, Investigation, Writing – original draft
Yang, M.: Methodology, Investigation, Writing – original draft

• Authors: Liu, Q., Yang, M., Shen, S., Gong, C., and Lan, Z.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Open Forum Infectious Diseases
• Publisher: Oxford University Press
• ISSN: 2328-8957
• ISSN (Online): 2328-8957
• Published Online: 13 October 2023
• Copyright Holders: Copyright: © The Author(s) 2023
• First Published: First published in Open Forum Infectious Diseases 10(11): ofad509
• Publisher Policy: Reproduced under a Creative Commons licence