Rhodes, S. et al. (2023) The potential contribution of vaccination uptake to occupational differences in risk of SARS-CoV-2: Analysis of the ONS COVID-19 Infection Survey. Occupational and Environmental Medicine, (doi: 10.1136/oemed-2023-108931) (Early Online Publication)
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Abstract
Objectives To assess variation in vaccination uptake across occupational groups as a potential explanation for variation in risk of SARS-CoV-2 infection. Design We analysed data from the UK Office of National Statistics COVID-19 Infection Survey linked to vaccination data from the National Immunisation Management System in England from 1 December 2020 to 11 May 2022. We analysed vaccination uptake and SARS-CoV-2 infection risk by occupational group and assessed whether adjustment for vaccination reduced the variation in risk between occupational groups. Results Estimated rates of triple vaccination were high across all occupational groups (80% or above), but were lowest for food processing (80%), personal care (82%), hospitality (83%), manual occupations (84%) and retail (85%). High rates were observed for individuals working in health (95% for office based, 92% for those in patient-facing roles) and education (91%) and office-based workers not included in other categories (90%). The impact of adjusting for vaccination when estimating relative risks of infection was generally modest (ratio of hazard ratios across all occupational groups reduced from 1.37 to 1.32), but was consistent with the hypothesis that low vaccination rates contribute to elevated risk in some groups. Conclusions Variation in vaccination coverage might account for a modest proportion of occupational differences in infection risk. Vaccination rates were uniformly very high in this cohort, which may suggest that the participants are not representative of the general population. Accordingly, these results should be considered tentative pending the accumulation of additional evidence.
| Item Type: | Articles |
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| Additional Information: | This work was supported with funding from the ONS (ONS Ref PU22-0205). MG, NP, MvT, JW and SR acknowledge funding through the National Core Study ’PROTECT’ programme, managed by the Health and Safety Executive on behalf of HM Government. TK, ED and SVK acknowledge funding from the Medical Research Council (MRC; MC_UU_00022/2) and the Chief Scientist Office (CSO; SPHSU17). SVK also acknowledges funding from a NRS Senior Clinical Fellowship (SCAF/15/02). |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Katikireddi, Professor Vittal and Demou, Dr Evangelia and Kromydas, Dr Theocharis |
| Authors: | Rhodes, S., Demou, E., Wilkinson, J., Cherrie, M., Edge, R., Gittins, M., Katikireddi, S. V., Kromydas, T., Mueller, W., Pearce, N., and van Tongeren, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
| Journal Name: | Occupational and Environmental Medicine |
| Publisher: | BMJ Publishing Group |
| ISSN: | 1351-0711 |
| ISSN (Online): | 1470-7926 |
| Copyright Holders: | Copyright: © Author(s) (or their employer(s)) 2023 |
| First Published: | First published in Occupational and Environmental Medicine 2023 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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