Intact mismatch negativity responses in clinical high-risk for psychosis and first-episode psychosis: evidence from source-reconstructed event-related fields and time-frequency data

Dheerendra, P. , Grent-'t-Jong, T. , Gajwani, R. , Gross, J. , Gumley, A. I. , Krishnadas, R. , Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F. and Uhlhaas, P. J. (2023) Intact mismatch negativity responses in clinical high-risk for psychosis and first-episode psychosis: evidence from source-reconstructed event-related fields and time-frequency data. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, (doi: 10.1016/j.bpsc.2023.09.006) (PMID:37778724) (Early Online Publication)

Abstract

Background: To examine whether Mismatch Negativity (MMN) Responses are impaired in participants at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) patients and whether MMN-deficits predict clinical outcomes in CHR-Ps. Methods: Magnetoencephalography (MEG) data were collected during a duration-deviant MMN-paradigm for a group of 116 CHR-P participants, 33 FEP patients, (15 antipsychotic-naïve), a psychosis-risk-negative group (CHR-N: n=38) with substance abuse and affective disorder and 49 healthy controls (HC). Analysis of group differences of source-reconstructed event-related fields as well as time-frequency and inter-trial-phase-coherence (ITPC) focused on bilateral Heschl’s gyri and superior temporal gyri. Results: Significant MMNm responses were found across participants in bilateral Heschl’s gyrus and superior temporal gyri. However, MMN-amplitude as well as time-frequency and ITPC-responses were intact in CHR-P and FEP-patients relative to HC. Furthermore, MMN-deficits were not related to persistent attenuated psychotic symptoms nor transitions to psychosis in CHR-Ps. Conclusions: Our data suggest that MMNm responses in MEG-data are not impaired in early-stage psychosis and may not predict clinical outcomes in CHR-P participants.

• Item Type: Articles
• Status: Early Online Publication
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Uhlhaas, Professor Peter and Gross, Professor Joachim and Grent-'T-Jong, Dr Tineke and Dheerendra, Dr Pradeep and Gumley, Professor Andrew and Gajwani, Dr Ruchika and Krishnadas, Dr Rajeev
• Authors: Dheerendra, P., Grent-'t-Jong, T., Gajwani, R., Gross, J., Gumley, A. I., Krishnadas, R., Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., and Uhlhaas, P. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
• Publisher: Elsevier
• ISSN: 2451-9022
• ISSN (Online): 2451-9022
• Published Online: 30 September 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2023
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
190713		Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker Approach	Peter Uhlhaas	Medical Research Council (MRC)	MR/L011689/1	SPN - Centre for Cognitive Neuroimaging (CCNi)