Short- and long-term effects of nutritional state on IGF-1 levels in nestlings of a wild passerine

Lodjak, J., Boonekamp, J. , Lendvai, Á. Z. and Verhulst, S. (2023) Short- and long-term effects of nutritional state on IGF-1 levels in nestlings of a wild passerine. Oecologia, 203, pp. 27-35. (doi: 10.1007/s00442-023-05445-3) (PMID:37676486) (PMCID:PMC10615909)

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Growth trajectories of young animals are intimately connected to their fitness prospects, but we have little knowledge of growth regulation mechanisms, particularly in the wild. Insulin-like growth factor 1 (IGF-1) is a central hormone in regulating resource allocation, with higher IGF-1 levels resulting in more growth. IGF-1 levels generally increase in conjunction with nutritional state, but whether IGF-1 levels are adjusted in response to current nutrient availability or to the nutrient availability integrated over a longer term is not well known. We tested for such effects by supplementary feeding the jackdaw (Corvus monedula) nestlings in experimentally reduced or enlarged broods with either water (control) or a food solution; these manipulations have long- and short-term effects on the nutritional state, respectively. Baseline plasma IGF-1 levels were higher in reduced broods. Food supplementation induced an increase in plasma IGF-1 levels measured one hour later, and this effect was significantly more substantial in nestlings in reduced broods. Changes in plasma IGF-1 levels increased with increased retention of the supplementary food, which was higher in reduced broods, explaining the stronger IGF-1 response. Thus, IGF-1 levels respond to short-term variations in the nutritional state, but this effect is amplified by longer-term variations in the nutritional state. We discuss our findings using a graphical model that integrates the results of the two treatments.

Item Type:Articles
Additional Information:Funding: Eesti Teadusagentuur, PUTJD700; Jaanis Lodjak, MOBTP169; Jaanis Lodjak, National Research, Development and Innovation Ofce (HU), K139021, Ádám Z. Lendvai.
Glasgow Author(s) Enlighten ID:Boonekamp, Dr Jelle
Authors: Lodjak, J., Boonekamp, J., Lendvai, Á. Z., and Verhulst, S.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Oecologia
ISSN (Online):1432-1939
Published Online:07 September 2023
Copyright Holders:Copyright © 2023 The Authors
First Published:First published in Oecologia 203:27–35
Publisher Policy:Reproduced under a Creative Commons licence

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