Pérez, M. G. , Grecco, A. and Rosenzvit, M. C. (2022) MicroRNA interference. In: Xiao, J. (ed.) MicroRNA: From Bench to Bedside. Elsevier (Academic Press), pp. 33-52. ISBN 9780323897747 (doi: 10.1016/B978-0-323-89774-7.00017-0)
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Abstract
MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression in many cellular pathways, and play critical functions in developmental and pathological processes. Thus, alterations in the levels of individual or entire families of miRNAs are associated with the pathogenesis of a wide range of human and animal diseases. Indeed, disease-associated miRNAs represent a new class of targets for the development of miRNA-based therapeutic modalities. The interest in miRNA research has accelerated the development of several in vitro and in vivo experimental approaches for probing miRNA functions by means of miRNA interference (RNAi). This chapter will summarize and assess the technologies that have demonstrated their efficacy and reliability in inhibiting and enhancing miRNA expression. Furthermore, we describe the most commonly used in vivo delivery strategies for miRNAi. Finally, we critically summarize recent progress of therapeutics based on miRNAi and their impact in human diseases.
| Item Type: | Book Sections |
|---|---|
| Status: | Published |
| Glasgow Author(s) Enlighten ID: | Perez, Dr Matias |
| Authors: | Pérez, M. G., Grecco, A., and Rosenzvit, M. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Publisher: | Elsevier (Academic Press) |
| ISBN: | 9780323897747 |
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