Nappi, F., Avtaar Singh, S. S., Jitendra, V., Alzamil, A. and Schoell, T. (2023) Roles of microRNAs in the cardiovascular system. International Journal of Molecular Sciences, 24(18), 14277. (doi: 10.3390/ijms241814277) (PMID:37762578) (PMCID:PMC10531750)
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Abstract
The discovery of miRNAs and their role in disease represent a significant breakthrough that has stimulated and propelled research on miRNAs as targets for diagnosis and therapy. Cardiovascular disease is an area where the restrictions of early diagnosis and conventional pharmacotherapy are evident and deserve attention. Therefore, miRNA-based drugs have significant potential for development. Research and its application can make considerable progress, as seen in preclinical and clinical trials. The use of miRNAs is still experimental but has a promising role in diagnosing and predicting a variety of acute coronary syndrome presentations. Its use, either alone or in combination with currently available biomarkers, might be adopted soon, particularly if there is diagnostic ambiguity. In this review, we examine the current understanding of miRNAs as possible targets for diagnosis and treatment in the cardiovascular system. We report on recent advances in recognising and characterising miRNAs with a focus on clinical translation. The latest challenges and perspectives towards clinical application are discussed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Singh, Mr Sanjeet |
| Creator Roles: | Singh, S.Methodology, Software, Validation, Formal analysis, Data curation, Writing – review and editing, Visualization, Supervision |
| Authors: | Nappi, F., Avtaar Singh, S. S., Jitendra, V., Alzamil, A., and Schoell, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | International Journal of Molecular Sciences |
| Publisher: | MDPI |
| ISSN: | 1661-6596 |
| ISSN (Online): | 1422-0067 |
| Copyright Holders: | Copyright: © 2023 by the authors |
| First Published: | First published in International Journal of Molecular Sciences 24(18): 14277 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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