Changes in oxygenation levels during moderate altitude simulation (hypoxia-induced): a pilot study investigating the impact of skin pigmentation in pulse oximetry

Ochoa-Gutierrez, V. , Guerrero-Zuñiga, S., Reboud, J. , Pazmino Betancourth, M. , Harvey, A. R. and Cooper, J. M. (2022) Changes in oxygenation levels during moderate altitude simulation (hypoxia-induced): a pilot study investigating the impact of skin pigmentation in pulse oximetry. In: Scholkmann, F., LaManna, J. and Wolf, U. (eds.) Oxygen Transport to Tissue XLIII. Series: Advances in Experimental Medicine and Biology (AEMB), 1395. Springer: Cham, Switzerland, pp. 391-396. ISBN 9783031141898 (doi: 10.1007/978-3-031-14190-4_64)

Abstract

The current COVID-19 pandemic has shown us that the pulse oximeter is a key medical device for monitoring blood-oxygen levels non-invasively in patients with chronic or acute illness. It has also emphasised limitations in accuracy for individuals with darker skin pigmentation, calling for new methods to provide better measurements. The aim of our study is to identify the impact of skin pigmentation on pulse oximeter measurements. We also explored the benefits of a multi-wavelength approach with an induced change of arterial oxygen saturation. A total of 20 healthy volunteers were recruited. We used time domain diffuse reflectance spectroscopy (TDDRS) from a broad band light source, collecting spectra from the index finger along with three different pulse oximeters used simultaneously for monitoring purposes. Five acute hypoxic events were induced by administering 11% FiO2, produced by a Hypoxico altitude training system, for 120 sec through a face mask with a one-way valve. Our multi-wavelength approach revealed a correlation between the signature of skin pigmentation and the dynamic range of oxygen saturation measurements. Principal component analysis (PCA) showed separation between a range of different pigmented volunteers (PC1 = 56.00%) and oxygen saturation (PC2 = 22.99%). This emphasises the need to take into account skin pigmentation in oximeter measurements. This preliminary study serves to validate the need to better understand the impact of skin pigmentation absorption on optical readings in pulse oximeters. Multi-wavelength approaches have the potential to enable robust and accurate measurements across diverse populations.

• Item Type: Book Sections
• Additional Information: Proceedings of the 48th Annual Meeting of the International Society on Oxygen Transport to Tissue 2021. We acknowledge support provided by INER and The University of Glasgow, especially to INER’s Principal Dr. Jorge Salas-Hernandez and Dr. Laura Gochicoa-Rangel. V. Ochoa-Gutierrez acknowledges financial support from the Mexican National Science and Technology Council and the Ministry of Energy (CONACyT – SENER) through scholarship No. 593603 and the Secretariat of Public Education (SEP) through scholarship BC-9517/36248.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ochoa Gutierrez, Mr Victor and Cooper, Professor Jonathan and Pazmino Betancourth, Mr Mauro and Reboud, Professor Julien
• Authors: Ochoa-Gutierrez, V., Guerrero-Zuñiga, S., Reboud, J., Pazmino Betancourth, M., Harvey, A. R., and Cooper, J. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine; College of Science and Engineering > School of Engineering; College of Science and Engineering > School of Engineering > Biomedical Engineering
• Publisher: Springer
• ISBN: 9783031141898
• Copyright Holders: Copyright © Springer Nature Switzerland AG 2022
• First Published: First published in Oxygen Transport to Tissue XLIII: 391-396
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

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