Scougall, K. et al. (2023) Predictors of surgical complications in boys with hypospadias: data from an international registry. World Journal of Pediatric Surgery, 6, e000599. (doi: 10.1136/wjps-2023-000599) (PMID:37860275) (PMCID:PMC10582860)
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Abstract
Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence. Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates. Results: Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications. Conclusions: Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.
| Item Type: | Articles |
|---|---|
| Additional Information: | This study was funded by Chief Scientist Office (PCL/21/05). AKL-H is funded by an NES/CSO Clinical Lectureship. AKL-H is supported by the Joint NES/CSO Postdoctoral Clinical Lectureship Scheme. SFA and JB are supported by the European Union’s Health Programme (2014–2020) on the EuRRECa project ‘777215/EuRRECa’ and SFA is also supported by the European Union’s Health Programme (2014–2020) on the EuRR-Bone project ‘946831/EuRR-Bone. The I-DSD Registry was developed using support from the Medical Research Council (G1100236), the Seventh European Union Framework Program (201444), the European Society for Paediatric Endocrinology Research Unit and is maintained through fees applied for data access and through its biennial symposiums. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Markosyan, Dr Renata and Bryce, Dr Jillian and Gazdagh, Dr Gabriella and Boal, Dr Rachel and Scougall, Kathryn and Ahmed, Professor Syed Faisal and Stancampiano, Dr Marianna and Lucas-Herald, Dr Angela |
| Authors: | Scougall, K., Bryce, J., Baronio, F., Boal, R. L., Castera, J. R., Castro, S., Cheetham, T., Corrêa Costa, E., Darendeliler, F., Davies, J. H., Dirlewanger, M., Gazdagh, G., Globa, E., Guerra-Junior, G., Guran, T., Herrmann, G., Holterhus, P.- M., Karagözlü Akgül, A., Markosyan, R., McElreavey, K., Lopes Miranda, M., Nordenstrom, A., O’Toole, S., Poyrazoglu, S., Russo, G., Schwitzgebel, V., Stancampiano, M., Steigert, M., Ahmed, S. F., and Lucas-Herald, A. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | World Journal of Pediatric Surgery |
| Publisher: | BMJ Publishing Group |
| ISSN: | 2516-5410 |
| ISSN (Online): | 2516-5410 |
| Published Online: | 11 October 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in World Journal of Pediatric Surgery 6:e000599 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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