Association of ABO blood group with delayed cerebral ischemia and clinical outcomes following aneurysmal subarachnoid hemorrhage in Pakistan

Azeem, S., Ashraf, M. , Ahmad Kamboh, U., Asif Raza, M., Farooq, M., Ahmad Cheema, H., Tariq, S., Choudhary, N., Shahzad Hussain, S. and Ashraf, N. (2023) Association of ABO blood group with delayed cerebral ischemia and clinical outcomes following aneurysmal subarachnoid hemorrhage in Pakistan. Asian Journal of Neurosurgery, 18(1), pp. 108-116. (doi: 10.1055/s-0043-1760859) (PMID:37056873) (PMCID:PMC10089742)

Abstract

Background: The ABO blood type, due to its various hemostaseologic properties, has been associated with several vascular diseases, including aneurysmal subarachnoid hemorrhage (aSAH). However, the role of ABO blood type in delayed cerebral ischemia (DCI) onset and other clinical outcomes after aSAH is largely unexplored. This study aimed to investigate the association between ABO blood type and outcomes after aSAH, primarily DCI. Methods: A retrospective analysis was made on the data collected from 175 aSAH patients at a tertiary supraregional neurosurgery department over 5 years. Socio-demographic factors, clinical variables (DCI, mFG, WFNS grade, and Glasgow Outcome Scale at discharge), EVD placement, and aneurysm size were analyzed for their association with ABO blood type. Results: DCI was reported in 25% of patients with ‘O’ blood type and 9.6% with ‘non-O’ blood type. A stepwise logistic regression model showed that after adjusting for BMI, mFG, WFNS grade, and EVD placement, ‘O’ type blood group was an independent risk factor for DCI, greatly increasing the risk of DCI as compared to ‘non-O’ type groups (OR = 3.27, 95% CI: 1.21–8.82). Conclusion: This study provides evidence that individuals with ‘O’ blood type may have a higher risk of DCI onset after aSAH. However, further studies are essential to address the limitations of our work and confirm our findings.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ashraf, Dr Mohammad
• Authors: Azeem, S., Ashraf, M., Ahmad Kamboh, U., Asif Raza, M., Farooq, M., Ahmad Cheema, H., Tariq, S., Choudhary, N., Shahzad Hussain, S., and Ashraf, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Asian Journal of Neurosurgery
• Publisher: Georg Thieme
• ISSN: 1793-5482
• ISSN (Online): 2248-9614
• Copyright Holders: Copyright © 2023 sian Congress of Neurological Surgeons
• First Published: First published in Asian Journal of Neurosurgery 18(1):108-116
• Publisher Policy: Reproduced under a Creative Commons License