Evans, N. P. , Bellingham, M. , Elcombe, C. S., Ghasemzadeh-Hasankolaei, M., Lea, R. G., Sinclair, K. D. and Padmanabhan, V. (2023) Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep. Environmental Toxicology and Pharmacology, 102, 104257. (doi: 10.1016/j.etap.2023.104257) (PMID:37659607)
![[img]](https://eprints.gla.ac.uk/style/images/fileicons/text.png) |
Text
305743.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 1MB |
Abstract
Humans are ubiquitously exposed to complex mixtures of environmental chemicals (ECs). This study characterised changes in post-natal and peripubertal growth, and the activation of the reproductive axis, in male and female offspring of sheep exposed to a translationally relevant EC mixture (in biosolids), during pregnancy. Birthweight in both sexes was unaffected by gestational biosolids exposure. In contrast to females (unaffected), bodyweight in biosolids males was significantly lower than controls across the peripubertal period, however, they exhibited catch-up growth eventually surpassing controls. Despite weighing less, testosterone concentrations were elevated earlier, indicative of early puberty in the biosolids males. This contrasted with females in which the mean date of puberty (first progesterone cycle) was delayed. These results demonstrate that developmental EC-mixture exposure has sexually dimorphic effects on growth, puberty and the relationship between body size and puberty. Such programmed metabolic/reproductive effects could have significant impacts on human health and wellbeing.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the National Institutes of Health R01 ES030374. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ghasemzadeh Hasankolaei, Dr Mohammad and Bellingham, Dr Michelle and Elcombe, Christopher and Evans, Professor Neil |
| Creator Roles: | Evans, N.Conceptualization, Methodology, Writing – original draft Bellingham, M.Conceptualization, Methodology, Writing – review and editing Elcombe, C.Methodology, Writing – review and editing Ghasemzadeh Hasankolaei, M.Writing – review and editing |
| Authors: | Evans, N. P., Bellingham, M., Elcombe, C. S., Ghasemzadeh-Hasankolaei, M., Lea, R. G., Sinclair, K. D., and Padmanabhan, V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Environmental Toxicology and Pharmacology |
| Publisher: | Elsevier |
| ISSN: | 1382-6689 |
| ISSN (Online): | 1872-7077 |
| Published Online: | 01 September 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Environmental Toxicology and Pharmacology 102: 104257 |
| Publisher Policy: | Reproduced under a Creative Commons license |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information