Bhattacharya, S., Bhattacharyya, T., Khanra, S. , Banerjee, R. and Dash, J. (2023) Nucleoside-derived metallohydrogel induces cell death in leishmania parasites. ACS Infectious Diseases, (doi: 10.1021/acsinfecdis.2c00635) (PMID:37606735) (Early Online Publication)
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Abstract
Self-assembled hydrogels by virtue of their unique 3D network and tunability have extensively been explored for bio-medical applications like tissue engineering, delivery and release of therapeutic agents, etc. Herein, we demonstrate for the first-time nucleoside-based biocompatible hydrogels with a remarkable leishmanicidal effect against both Leishmania major promastigotes and amastigotes and no cytotoxic effect on the macrophage cell line. In this work, a series of biocompatible hydrogels have been synthesized by silver ion-driven self-assembly of natural nucleoside and nucleotide-like cytidine and 5′-GMP. The supramolecular metallogel obtained from the assembly of cytidine and boronic acid is capable of inducing apoptotic-like cell death of protozoan parasite by causing damage to the membrane as well as DNA. These hydrogels could find promising applications in combating cutaneous leishmaniasis by topical treatment.
| Item Type: | Articles |
|---|---|
| Additional Information: | J.D. thanks DST SERB-CRG project [CRG/2021/004525], Wellcome Trust/ DBT India Alliance Fellowship [grant number IA/S/18/2/503986] and Technical Research Centre (TRC) of IACS for funding. S.B. thanks ICMR for a research fellowship. T.B. thanks CSIR-India for a research fellowship. |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Khanra, Dr Supriya |
| Authors: | Bhattacharya, S., Bhattacharyya, T., Khanra, S., Banerjee, R., and Dash, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | ACS Infectious Diseases |
| Publisher: | American Chemical Society |
| ISSN: | 2373-8227 |
| ISSN (Online): | 2373-8227 |
| Published Online: | 22 August 2023 |
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