Nucleoside-derived metallohydrogel induces cell death in leishmania parasites

Bhattacharya, S., Bhattacharyya, T., Khanra, S. , Banerjee, R. and Dash, J. (2023) Nucleoside-derived metallohydrogel induces cell death in leishmania parasites. ACS Infectious Diseases, (doi: 10.1021/acsinfecdis.2c00635) (PMID:37606735) (Early Online Publication)

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Self-assembled hydrogels by virtue of their unique 3D network and tunability have extensively been explored for bio-medical applications like tissue engineering, delivery and release of therapeutic agents, etc. Herein, we demonstrate for the first-time nucleoside-based biocompatible hydrogels with a remarkable leishmanicidal effect against both Leishmania major promastigotes and amastigotes and no cytotoxic effect on the macrophage cell line. In this work, a series of biocompatible hydrogels have been synthesized by silver ion-driven self-assembly of natural nucleoside and nucleotide-like cytidine and 5′-GMP. The supramolecular metallogel obtained from the assembly of cytidine and boronic acid is capable of inducing apoptotic-like cell death of protozoan parasite by causing damage to the membrane as well as DNA. These hydrogels could find promising applications in combating cutaneous leishmaniasis by topical treatment.

Item Type:Articles
Additional Information:J.D. thanks DST SERB-CRG project [CRG/2021/004525], Wellcome Trust/ DBT India Alliance Fellowship [grant number IA/S/18/2/503986] and Technical Research Centre (TRC) of IACS for funding. S.B. thanks ICMR for a research fellowship. T.B. thanks CSIR-India for a research fellowship.
Status:Early Online Publication
Glasgow Author(s) Enlighten ID:Khanra, Dr Supriya
Authors: Bhattacharya, S., Bhattacharyya, T., Khanra, S., Banerjee, R., and Dash, J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:ACS Infectious Diseases
Publisher:American Chemical Society
ISSN (Online):2373-8227
Published Online:22 August 2023

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