The ARF GTPase regulatory network in collective invasion and metastasis

Nikolatou, K. , Bryant, D. M. and Sandilands, E. (2023) The ARF GTPase regulatory network in collective invasion and metastasis. Biochemical Society Transactions, 51(4), pp. 1559-1569. (doi: 10.1042/BST20221355) (PMID:37622523) (PMCID:PMC10586773)

Abstract

The ability to remodel and move cellular membranes, and the cargoes regulated by these membranes, allows for specialised functions to occur in distinct regions of the cell in a process known as cellular polarisation. The ability to collectively co-ordinate such polarisation between cells allows for the genesis of multicellularity, such as the formation of organs. During tumourigenesis, the rules for such tissue polarisation become dysregulated, allowing for collective polarity rearrangements that can drive metastasis. In this review, we focus on how membrane trafficking underpins collective cell invasion and metastasis in cancer. We examine this through the lens of the ADP-ribosylation factor (ARF) subfamily of small GTPases, focusing on how the ARF regulatory network — ARF activators, inactivators, effectors, and modifications — controls ARF GTPase function.

• Item Type: Articles
• Additional Information: Supported by a start-up package from the University of Glasgow and a UK Research and Innovation Future Leader Fellowship to D.M.B. (MR/T040769/1). K.N. was supported by a Cancer Research UK Glasgow Centre PhD studentship (C7932/A25170).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Nikolatou, Konstantina and Bryant, Dr David and Sandilands, Dr Emma
• Authors: Nikolatou, K., Bryant, D. M., and Sandilands, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochemical Society Transactions
• Publisher: Portland Press
• ISSN: 0300-5127
• ISSN (Online): 1470-8752
• Published Online: 25 August 2023
• Copyright Holders: Copyright © 2023 The Author(s)
• First Published: First published in Biochemical Society Transactions 51(4):1559–1569
• Publisher Policy: Reproduced under a Creative Commons license

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
307853		OrgTIP: A transplantable organoid-to-in vivo pipeline for targeting phospholipid metabolism to stop colorectal carcinoma	David Bryant	Medical Research Council (MRC)	MR/T040769/1	SCS - Beatson Institute for Cancer Research
300448		Non-clinical Training Award Cycle 3 2017	Owen Sansom	Cancer Research UK (CRUK)	C7932/A25170	SCS - Beatson Institute for Cancer Research