Nunez-Corcuera, B., Birch, J. and Williams, J. G. (2011) A SET/MYND chromatin re-modelling protein regulates Dictyostelium prespore patterning. International Journal of Developmental Biology, 55(2), pp. 205-208. (doi: 10.1387/ijdb.113309bn) (PMID:21671223) (PMCID:PMC3586672)
Full text not currently available from Enlighten.
Abstract
SmdA is a Dictyostelium orthologue of the SET/MYND chromatin re-modelling proteins. In developing structures derived from a null mutant for smdA (a smdA- strain), prestalk patterning is normal, but using a prespore lacZ reporter fusion, there is ectopic accumulation of beta-galactosidase in the prestalk region. As wild type slugs migrate, there is continual forward movement and re-differentiation of prespore cells into prestalk cells. Thus, a potential explanation for the ectopic reporter localization in smdA null prestalk cells is an increased rate of re-differentiation and anterior movement of prespore cells. In support of this notion, analysis of an unstable lacZ reporter, driven by the prespore promoter, reveals a normal staining pattern in the smdA- strain. We suggest that one or more genes regulated by SmdA acts to repress prespore re-specification.
| Item Type: | Articles |
|---|---|
| Additional Information: | The work was initially funded by an MRC project grant (MRC G0600244 to JGW) and was completed with the support of a Wellcome Trust program grant (082579/Z to JGW). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Birch, Dr Joanna |
| Authors: | Nunez-Corcuera, B., Birch, J., and Williams, J. G. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | International Journal of Developmental Biology |
| Publisher: | University of the Basque Country Press |
| ISSN: | 0214-6282 |
| ISSN (Online): | 1696-3547 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details