Nothnagel, N. , Morgan, T., Symon, A., Muckli, L. and Goense, J. (2023) Optimized Signal Saturation for Fast Functional Line-Scanning of Cortical Layers. International Society for Magnetic Resonance in Medicine (ISMRM 2023), Toronto, ON, Canada, 03-08 June 2023.
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Abstract
Layer-dependent fMRI is typically performed at sampling rates below 1 Hz and voxel sizes of 0.7-0.9 mm3 containing signal from multiple anatomical layers. Line-scanning can enhance spatial resolution to 0.2-0.4 mm while maintaining sub-second TR. It is therefore an ideal method to study temporal evolution of BOLD responses across cortical layers. However, current saturation schemes for human line-scanning suffer from broad saturation profiles that lead to signal contamination of BOLD responses from adjacent areas. We implemented line-scanning in humans with sharp line-profiles of 3 mm. Using this method, we show that cortical layers of M1 have unique BOLD time courses.
| Item Type: | Conference or Workshop Item |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Goense, Dr Jozien and Nothnagel, Dr Nils and Muckli, Professor Lars and Symon, Alison |
| Authors: | Nothnagel, N., Morgan, T., Symon, A., Muckli, L., and Goense, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
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