The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus

Willett, B.J. and Hosie, M.J. (1999) The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus. Molecular Membrane Biology, 16(1), pp. 67-72. (doi: 10.1080/096876899294779)

Abstract

Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. This article reviews the evidence for the involvement of chemokine receptors in FIV infection and contrasts these findings with similar studies on the primate lentiviruses HIV and SIV (simian immunodeficiency virus).

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hosie, Professor Margaret and Willett, Professor Brian
• Authors: Willett, B.J., and Hosie, M.J.
• Subjects: Q Science > QR Microbiology > QR355 Virology
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Molecular Membrane Biology
• Journal Abbr.: Mol Membr Biol.
• ISSN: 0968-7688
• First Published: First published in Molecular Membrane Biology 16(1):67-72
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.