Magnetic manipulation of Fe₃O₄@BaTiO₃ nanochains to regulate extracellular topographical and electrical cues

Zhang, Y. et al. (2023) Magnetic manipulation of Fe₃O₄@BaTiO₃ nanochains to regulate extracellular topographical and electrical cues. Acta Biomaterialia, 168, pp. 470-483. (doi: 10.1016/j.actbio.2023.07.029) (PMID:37495167)

Abstract

Magnetic fields play an essential role in material science and biomedical engineering. Magnetic-responsive materials can be arranged orderly in matrix to realize the construction of an aligned scaffold under magnetic induction. However, a single topological cue is insufficient to activate neural tissue regeneration, demanding more cues to promote regeneration synergistically, such as electrical stimulation and a biomimetic matrix. Herein, we propose one-dimensional (1D) magnetoelectric Fe3O4@BaTiO3 nanochains with controllable lengths under the regulation of a magnetic field. These nanochains can be oriented in the biomimetic hydrogel under magnetic guidance and induce the hydrogel microfiber to align along the direction of the nanochains, which is beneficial for cell-oriented outgrowth. This aligned hydrogel enabled wireless electrical stimulation mediated by magnetoelectric nanochains under magnetic stimulation, thereby activating the voltage-gated ion channel. Consequently, topological and electrical cues in this multifunctional biomimetic hydrogel synergistically enhanced the expression of neural functional proteins, facilitating synapse remodeling and neural regeneration. Predictably, the construction of multifunctional hydrogels based on low-cost and facile synthesis of magnetoelectric nanochains is an emerging patient-friendly and effective therapeutic strategy for neural or other tissue regeneration.

• Item Type: Articles
• Additional Information: This work was supported by the National Natural Science Foundation of China (grant number: 52273141 and 51973132), International Science and Technology Innovation Cooperation Foundation of Sichuan Province (grant number: 2022YFH0086).
• Keywords: Magnetoelectric materials, electrical stimulation, aligned hydrogel, contact guidance, neural regeneration
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Yin, Professor Huabing
• Authors: Zhang, Y., Su, B., Tian, Y., Yu, Z., Wu, X., Ding, J., Wu, C., Wei, D., Yin, H., Sun, J., and Fan, H.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Acta Biomaterialia
• Publisher: Elsevier
• ISSN: 1742-7061
• ISSN (Online): 1878-7568
• Published Online: 18 August 2023
• Copyright Holders: Copyright © 2023 Acta Materialia Inc
• First Published: First published in Acta Biomaterialia 168:470-483
• Publisher Policy: Reproduced in accordance with the publisher copyright policy