Abel, M.H., Baker, P.J., Charlton, H.M., Monteiro, A., Verhoeven, G., De Gendt, K., Guillou, F. and O'Shaughnessy, P.J. (2008) Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen. Endocrinology, 149(7), pp. 3279-3285. (doi: 10.1210/en.2008-0086)
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Abstract
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis. In this study we generated mice lacking both FSH receptors (FSHRKO) and androgen receptors on the Sertoli cell (SCARKO) to examine how FSH and androgen combine to regulate Sertoli cell function and spermatogenesis. Sertoli cell number in FSHRKO-SCARKO mice was reduced by about 50% but was not significantly different from FSHRKO mice. In contrast, total germ cell number in FSHRKO-SCARKO mice was reduced to 2% of control mice (and 20% of SCARKO mice) due to a failure to progress beyond early meiosis. Measurement of Sertoli cell-specific transcript levels showed that about a third were independent of hormonal action on the Sertoli cell, whereas others were predominantly androgen dependent or showed redundant control by FSH and androgen. Results show that FSH and androgen act through redundant, additive, and synergistic regulation of spermatogenesis and Sertoli cell activity. In addition, the Sertoli cell retains a significant capacity for activity, which is independent of direct hormonal regulation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | O'Shaughnessy, Professor Peter and Monteiro, Dr Ana and Baker, Dr Paul |
| Authors: | Abel, M.H., Baker, P.J., Charlton, H.M., Monteiro, A., Verhoeven, G., De Gendt, K., Guillou, F., and O'Shaughnessy, P.J. |
| Subjects: | Q Science > QP Physiology Q Science > QH Natural history > QH301 Biology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Endocrinology |
| Publisher: | Endocrine Society |
| ISSN: | 0013-7227 |
| ISSN (Online): | 1945-7170 |
| Published Online: | 10 April 2008 |
| Copyright Holders: | Copyright © 2008 Endocrine Society |
| First Published: | First published in Endocrinology 149(7):3279-3285 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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