Wireless-powering deep brain stimulation platform based on 1D-structured magnetoelectric nanochains applied in anti-epilepsy treatment

Zhang, Y. et al. (2023) Wireless-powering deep brain stimulation platform based on 1D-structured magnetoelectric nanochains applied in anti-epilepsy treatment. ACS Nano, 17(16), pp. 15796-15809. (doi: 10.1021/acsnano.3c03661)

Abstract

Electrical deep brain stimulation (DBS) is a top priority for pharmacoresistant epilepsy treatment, while less-invasive wireless DBS is an urgent priority but challenging. Herein, we developed a conceptual wireless DBS platform to realize local electric stimulation via 1D-structured magnetoelectric Fe3O4@BaTiO3 nanochains (FBC). The FBC was facilely synthesized via magnetic-assisted interface coassembly, possessing a higher electrical output by inducing larger local strain from the anisotropic structure and strain coherence. Subsequently, wireless magnetoelectric neuromodulation in vitro was synergistically achieved by voltage-gated ion channels and to a lesser extent, the mechanosensitive ion channels. Furthermore, FBC less-invasively injected into the anterior nucleus of the thalamus (ANT) obviously inhibited acute and continuous seizures under magnetic loading, exhibiting excellent therapeutic effects in suppressing both high voltage electroencephalogram signals propagation and behavioral seizure stage and neuroprotection of the hippocampus mediated via the Papez circuit similar to conventional wired-in DBS. This work establishes an advanced antiepilepsy strategy and provides a perspective for other neurological disorder treatment.

• Item Type: Articles
• Additional Information: The authors gratefully acknowledge financial support from National Natural Science Foundation of China (grant number: 52273141 and 51973132), International Science and Technology Innovation Cooperation Foundation of Sichuan Province (grant number: 2022YFH0086), and Science and Technology Program of Sichuan Province (grant number: 2021YJ0173).
• Keywords: Neural modulation, Electrical stimulation, Magnetoelectric Nanomaterials, Deep 16 brain stimulation, Epilepsy therapy
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Yin, Professor Huabing
• Authors: Zhang, Y., Wu, X., Ding, J., Su, B., Chen, Z., Xiao, Z., Wu, C., Wei, D., Sun, J., Luo, F., Yin, H., and Fan, H.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: ACS Nano
• Publisher: American Chemical Society
• ISSN: 1936-0851
• ISSN (Online): 1936-086X
• Published Online: 02 August 2023
• Copyright Holders: Copyright © 2023 American Chemical Society
• First Published: First published in ACS Nano 17(16):15796–15809
• Publisher Policy: Reproduced in accordance with the publisher copyright policy