Sánchez-González, J., Fernandez-Jiménez, R., Nothnagel, N. D. , López-Martín, G., Fuster, V. and Ibañez, B. (2015) Optimization of dual-saturation single bolus acquisition for quantitative cardiac perfusion and myocardial blood flow maps. Journal of Cardiovascular Magnetic Resonance, 17, 21. (doi: 10.1186/s12968-015-0116-2) (PMID:25880970) (PMCID:PMC4332925)
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Abstract
Background: In-vivo quantification of cardiac perfusion is of great research and clinical value. The dual-bolus strategy is universally used in clinical protocols but has known limitations. The dual-saturation acquisition strategy has been proposed as a more accurate alternative, but has not been validated across the wide range of perfusion rates encountered clinically. Dual-saturation acquisition also lacks a clinically-applicable procedure for optimizing parameter selection. Here we present a comprehensive validation study of dual-saturation strategy in vitro and in vivo. Methods: The impact of saturation time and profile ordering in acquisitions was systematically analyzed in a phantom consisting of 15 tubes containing different concentrations of contrast agent. In-vivo experiments in healthy pigs were conducted to evaluate the effect of R2* on the definition of the arterial input function (AIF) and to evaluate the relationship between R2* and R1 variations during first-pass of the contrast agent. Quantification by dual-saturation perfusion was compared with the reference-standard dual-bolus strategy in 11 pigs with different grades of myocardial perfusion. Results: Adequate flow estimation by the dual-saturation strategy is achieved with myocardial tissue saturation times around 100 ms (always <30 ms of AIF), with the lowest echo time, and following a signal model for contrast conversion that takes into account the residual R2* effect and profile ordering. There was a good correlation and agreement between myocardial perfusion quantitation by dual-saturation and dual-bolus techniques (R2 = 0.92, mean difference of 0.1 ml/min/g; myocardial perfusion ranges between 0.18 and 3.93 ml/min/g). Conclusions: The dual-saturation acquisition strategy produces accurate estimates of absolute myocardial perfusion in vivo. The procedure presented here can be applied with minimal interference in standard clinical procedures.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Nothnagel, Dr Nils |
Authors: | Sánchez-González, J., Fernandez-Jiménez, R., Nothnagel, N. D., López-Martín, G., Fuster, V., and Ibañez, B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Journal of Cardiovascular Magnetic Resonance |
Publisher: | BioMed Central |
ISSN: | 1097-6647 |
ISSN (Online): | 1532-429X |
Copyright Holders: | Copyright © 2015 Sánchez-González et al.; |
First Published: | First published in Journal of Cardiovascular Magnetic Resonance 17:21 |
Publisher Policy: | Reproduced under a Creative Commons license |
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