Cao, G. et al. (2023) Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment. EMBO Journal, 42(16), e110757. (doi: 10.15252/embj.2022110757) (PMID:37427448)
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Abstract
The tumor microenvironment (TME) directly determines patients' outcomes and therapeutic efficiencies. An in-depth understanding of the TME is required to improve the prognosis of patients with cervical cancer (CC). This study conducted single-cell RNA and TCR sequencing of six-paired tumors and adjacent normal tissues to map the CC immune landscape. T and NK cells were highly enriched in the tumor area and transitioned from cytotoxic to exhaustion phenotypes. Our analyses suggest that cytotoxic large-clone T cells are critical effectors in the antitumor response. This study also revealed tumor-specific germinal center B cells associated with tertiary lymphoid structures. A high-germinal center B cell proportion in patients with CC is predictive of improved clinical outcomes and is associated with elevated hormonal immune responses. We depicted an immune-excluded stromal landscape and established a joint model of tumor and stromal cells to predict CC patients' prognosis. The study revealed tumor ecosystem subsets linked to antitumor response or prognosis in the TME and provides information for future combinational immunotherapy.
| Item Type: | Articles |
|---|---|
| Additional Information: | This study was supported by the National Key R&D Program of China (No. 2021YFC2701200, 2022YFA1106000), the National Natural Science Foundation of China (No. 82273091, 32170660, 31801059, 81872290, 82203512), the Shanghai Science and Technology Development Foundation (No. 21S31905100), the East Hospital Initial Foundation (No. DFRC201917), the Shanghai Municipal Health Commission Foundation (202150001), the Shanghai Rising Star Program (No. 21QA1408200), and the Natural ScienceFoundation of Shanghai (No. 21ZR1467600). Quan Gu is funded by the Medical Research Council (MC_UU_1201412). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gu, Dr Quan |
| Creator Roles: | |
| Authors: | Cao, G., Yue, J., Ruan, Y., Han, Y., Zhi, Y., Lu, J., Liu, M., Xu, X., Wang, J., Gu, Q., Wen, X., Gao, J., Zhang, Q., Kang, J., Wang, C., and Li, F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | EMBO Journal |
| Publisher: | EMBO Press |
| ISSN: | 0261-4189 |
| ISSN (Online): | 1460-2075 |
| Published Online: | 10 July 2023 |
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