Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target

Wright, T. A., Gemmell, A. O., Tejeda, G. S. , Blair, C. M. and Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)

Abstract

Phosphodiesterase type 4 (PDE4) enzymes specifically hydrolyse cAMP in many cell signalling systems that are transduced by hormones and other primary messengers. The physiological function of the four PDE4 subfamilies (A, B, C and D) are numerous and varied due to the differentially localised plethora of isoforms that can be detected in cardiovascular, CNS and immune systems. Of the four subfamilies, least is known about PDE4C probably due to its restricted distribution pattern, scarcity of selective inhibitors and the lack of developed research tools. Here, for the first time, we chart the discovery of PDE4C, describe its regulation and highlight cancers where future development of PDE4C selective small molecules may have potential.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Blair, Dr Connor and Wright, Tom and Tejeda, Dr Gonzalo and Baillie, Professor George
• Authors: Wright, T. A., Gemmell, A. O., Tejeda, G. S., Blair, C. M., and Baillie, G. S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: International Journal of Biochemistry and Cell Biology
• Publisher: Elsevier
• ISSN: 1357-2725
• ISSN (Online): 1878-5875
• Published Online: 25 July 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in International Journal of Biochemistry and Cell Biology 162: 106453
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
308165		Institutional Translation Partnership Award	Gerard Graham	Wellcome Trust (WELLCOTR)	219390/Z/19/Z	MVLS - College Senior Management