Kirimi, M.T., Hoare, D., Holsgrove, M., Czyzewski, J., Mirzai, N., Mercer, J.R. and Neale, S. (2024) Detection of blood clots using a whole stent as an active implantable biosensor. Advanced Science, (doi: 10.1002/advs.202304748) (PMID:38342628) (Early Online Publication)
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Abstract
Many cardiovascular problems stem from blockages that form within the vasculature and often treatment includes fitting a stent through percutaneous coronary intervention. This offers a minimally invasive therapy but re-occlusion through restenosis or thrombosis formation often occurs post-deployment. Research is ongoing into the creation of smart stents that can detect the occurrence of further problems. In this study, it is shown that selectively metalizing a non-conductive stent can create a set of electrodes that are capable of detecting a build-up of material around the stent. The associated increase in electrical impedance across the electrodes is measured, testing the stent with blood clot to mimic thrombosis. It is shown that the device is capable of sensing different amounts of occlusion. The stent can reproducibly sense the presence of clot showing a 16% +/−3% increase in impedance which is sufficient to reliably detect the clot when surrounded by explanted aorta (one sample t-test, p = 0.009, n = 9). It is demonstrated that this approach can be extended beyond the 3D printed prototypes by showing that it can be applied to a commercially available stent and it is believed that it can be further utilized by other types of medical implants.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the BHF Centre of Research ExcellenceRE/13/5/30177, University of Glasgow, College of Medical, Veterinary andLife Sciences, Chief Science Office, Scotland Award (CSO): CGA/17/29; the Engineering and Physical Sciences Research Council (EP/S515401/1;EP/R020892/1), Welcome IAA 219390/Z/19/Z and a Medical ResearchCouncil Confidence in Concept (MRC-CiC) award. |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mirzai, Mr Nosrat and Czyzewski, Mr Jakub and Kirimi, Mr Mahmut and Holsgrove, Mr Michael and Hoare, Dr Daniel and Neale, Professor Steven and Mercer, Dr John |
| Authors: | Kirimi, M.T., Hoare, D., Holsgrove, M., Czyzewski, J., Mirzai, N., Mercer, J.R., and Neale, S. |
| College/School: | College of Science and Engineering > School of Engineering > Systems Power and Energy College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Advanced Science |
| Publisher: | Wiley |
| ISSN: | 2198-3844 |
| ISSN (Online): | 2198-3844 |
| Published Online: | 11 February 2024 |
| Copyright Holders: | Copyright: © 2024 The Authors |
| First Published: | First published in Advanced Science 2024 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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