Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region

Gulliver, C., Baillie, G. S. and Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9(9), (doi: 10.2144/fsoa-2023-0064) (PMID:37752916) (PMCID:PMC10518809)

Abstract

Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients & methods: RNA from biopsy punch samples of resected tumor tissue was analyzed via RNA sequencing. RT-qPCR was used to determine PDE4D7 score. Results: Numerous genomic sequences within the PDE4D coding region on Chr5q12 revealed similar mRNA expression profiles to PDE4D7. PART1 had a significantly similar expression pattern to PDE4D7 across samples, correlating with disease progression. However, many other genes also exhibited matched expression to PDE4D7, including miRNAs and lncRNAs. Conclusion: These novel PDE4D7-associated genes, many of which are previously uncharacterized in cancer, represent putative PCa biomarkers and could have mechanistic roles in PCa progression.

• Item Type: Articles
• Additional Information: This project was supported by the framework of CTMM (The Center for Translational Molecular Medicine; The Netherlands), PCMM project (grant no. 03O-203).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gulliver, Chloe and Baillie, Professor George and Hoffmann, Dr Ralf
• Authors: Gulliver, C., Baillie, G. S., and Hoffmann, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Future Science OA
• Publisher: Future Science
• ISSN: 2056-5623
• ISSN (Online): 2056-5623
• Published Online: 29 July 2023
• Copyright Holders: Copyright © 2023 The Authors
• First Published: First published in Future Science OA 9:9
• Publisher Policy: Reproduced under a Creative Commons license